Hussein Lama, Perrett Conal M
Department of Dermatology, University College London Hospital, London, UK.
J Dermatolog Treat. 2021 Dec;32(8):866-877. doi: 10.1080/09546634.2020.1720582. Epub 2020 Apr 13.
Sebaceous gland hyperplasia (SGH) is a benign cutaneous proliferation of the sebaceous glands that primarily affects the elderly group and frequently appears in individuals receiving long-term ciclosporin therapy such as organ transplant recipients. In the latter group, SGHs are usually multiple in number and occur predominantly on the face. Patients may find their appearance cosmetically undesirable and, in some cases, may result in significant negative psychological impact. There is, therefore, a demand for safe and effective treatment for SGH particularly in this patient group. A variety of treatment modalities have been previously described including electrodessication,surgery, cryotherapy, oral isotretinoin, lasers, and topical photodynamic therapy (PDT).
The objective of this paper is to review the various treatment modalities for SGH. We performed a systematic literature review using the National Library of Medicine's PubMed Database, whereby we included articles that met the following criteria: published in English, not focused on SGH in rhinophyma, studies with adult sample with SGH lesions, and studies with patients with SGH related to ciclosporin.
Our findings show that the literature is categorized according to the treatment modalities ranging from conventional techniques such as oral isotretinoin and cryotherapy to more advanced topical PDT, lasers and a combination of both. We found that effectiveness does not depend on the technique itself but instead on the number of lesions, financial cost, psychological factors, skin phototype and age.
Our work shows that SGH can be treated effectively by customizing the treatment modality according to different parameters, while effectively maintaining clearance of SGH lesions with best cosmetic outcome.
皮脂腺增生（SGH）是皮脂腺的一种良性皮肤增生，主要影响老年人群，且常见于接受长期环孢素治疗的个体，如器官移植受者。在后一组人群中，皮脂腺增生通常数量较多，主要出现在面部。患者可能会觉得其外观在美容方面不理想，在某些情况下，可能会造成严重的负面心理影响。因此，尤其对于这一患者群体，需要一种安全有效的皮脂腺增生治疗方法。此前已描述了多种治疗方式，包括电干燥法、手术、冷冻疗法、口服异维A酸、激光和局部光动力疗法（PDT）。
本文的目的是综述皮脂腺增生的各种治疗方式。我们使用美国国立医学图书馆的PubMed数据库进行了系统的文献综述，纳入了符合以下标准的文章：以英文发表、不聚焦于酒渣鼻中的皮脂腺增生、针对有皮脂腺增生病变的成人样本的研究以及针对与环孢素相关的皮脂腺增生患者的研究。
我们的研究结果表明，文献是根据治疗方式分类的，从口服异维A酸和冷冻疗法等传统技术到更先进的局部光动力疗法、激光以及两者结合的方法。我们发现有效性并不取决于技术本身，而是取决于病变数量、经济成本、心理因素、皮肤光型和年龄。
我们的研究表明，通过根据不同参数定制治疗方式，可以有效治疗皮脂腺增生，同时有效维持皮脂腺增生病变的清除，并获得最佳的美容效果。
