Nakagohri T, Kenmochi T, Kainuma O, Tokoro Y, Asano T
Second Department of Surgery, Chiba University School of Medicine, Japan.
Am J Surg. 1999 Oct;178(4):344-7. doi: 10.1016/s0002-9610(99)00192-0.
An increasing number of intraductal papillary mucinous tumors of the pancreas have been reported in recent years. The indolent character and favorable prognosis of this neoplasm have been described.
Intraductal papillary mucinous tumors were classified into main duct type (n = 8) and branch type (n = 28) according to the dominant location of the tumor. This single-institute study examined the clinicopathological features and outcome after surgical resection in patients with intraductal papillary mucinous tumors.
The gender, age, tumor size, and prognosis were quite similar for the main duct type and branch type groups. Branch type tumors were more frequently located in the head of the pancreas than were main duct type tumors. Histological examination revealed that 88% of main duct type tumors were adenocarcinomas; however, only 46% of branch type tumors were adenocarcinomas. Five-year survival rates for the patients with all main duct type tumors (n = 8), main duct type adenocarcinoma (n = 7), all branch type tumors (n = 28), and branch duct adenocarcinoma (n = 13) were 100%, 100%, 90.6%, and 90.9%, respectively.
Intraductal papillary mucinous tumors had a favorable prognosis after surgical treatment. A curative pancreatectomy should be indicated for this localized malignant tumor.
近年来，胰腺导管内乳头状黏液性肿瘤的报道日益增多。该肿瘤具有惰性特征及良好的预后已被描述。
根据肿瘤的主要位置，将导管内乳头状黏液性肿瘤分为主胰管型（n = 8）和分支胰管型（n = 28）。这项单中心研究检查了导管内乳头状黏液性肿瘤患者手术切除后的临床病理特征及预后。
主胰管型和分支胰管型组在性别、年龄、肿瘤大小及预后方面相当相似。分支胰管型肿瘤比主胰管型肿瘤更常位于胰头。组织学检查显示，88%的主胰管型肿瘤为腺癌；然而，仅46%的分支胰管型肿瘤为腺癌。所有主胰管型肿瘤（n = 8）、主胰管型腺癌（n = 7）、所有分支胰管型肿瘤（n = 28）及分支胰管型腺癌（n = 13）患者的5年生存率分别为100%、100%、90.6%和90.9%。
导管内乳头状黏液性肿瘤手术治疗后预后良好。对于这种局限性恶性肿瘤，应行根治性胰腺切除术。
