Dardik A, Lin J W, Gordon T A, Williams G M, Perler B A
Division of Vascular Surgery, Department of Surgery, The Johns Hopkins Hospital, Baltimore, MD 21287-4685, USA.
J Vasc Surg. 1999 Dec;30(6):985-95. doi: 10.1016/s0741-5214(99)70036-4.
The safety and efficacy of conventional abdominal aortic aneurysm (AAA) repair are undergoing increased examination in parallel with the development of less invasive repair methods. Because most published studies of elective AAA repair report operations performed in tertiary referral institutions and thus may not reflect the outcome in the surgical community at large, the current population-based study was undertaken to document the results obtained across a broad spectrum of clinical practice in a defined geographic area and to examine the factors that influence the outcomes.
The Maryland Health Services Cost Review Commission database was used to identify all the elective AAA repairs that were performed in all the nonfederal acute care hospitals in the state from 1990 to 1995.
Elective AAA repair was performed on 2335 patients (mean age, 70.4 years) in 46 of the 52 (88%) nonfederal acute care hospitals in the state, including seven high-volume (>100 cases), nine moderate-volume (50 to 99 cases), and 30 low-volume (<50 cases) institutions. The in-hospital mortality rate was 3.5% and increased significantly with advancing age: less than 65 years, 2.2%; 65 to 69 years, 2.5%; 70 to 79 years, 3.5%; and more than 80 years, 7.3% (P =.002). Mortality rates were higher for women (4.5% vs 3.2%; P =.17), for blacks (6.7% vs 3.2%; P =.046), and for patients with renal failure (11.8% vs 3. 4%; P =.11) but not for patients with hypertension, diabetes, heart disease, and pulmonary disease. The operative mortality rate was inversely correlated with hospital volume (4.3% in low-volume hospitals, 4.2% in moderate-volume hospitals, and 2.5% in high-volume hospitals; P =.08), although no differences were noted in the mean ages or comorbidity levels of patients who underwent operations in these three hospital populations. The operative mortality rate was inversely correlated with the experience of the individual surgeon: one case, 9.9%; two to nine cases, 4.9%; 10 to 49 cases, 2.8%; 50 to 99 cases, 2.9%; and more than 100 cases, 3.8% (P =.01). Multivariate analysis results identified patient age (P =. 002), low hospital volume (P =.039), and very low surgeon volume (P =.01) as independent predictors of operative mortality. The mean length of stay and mean hospital charges were 10.6 days and $17,589 and decreased with increasing surgeon volume: one case, 22.7 days/$32,800; two to nine cases, 10.6 days/$18,509; 10 to 49 cases, 10.0 days/$16,611; 50 to 99 cases, 10.9 days/$17,843; and more than 100 cases, 9.6 days/$16,682 (P <.0001/P <.0001).
Elective AAA repair is a safe procedure in contemporary practice in Maryland. Operative risk is increased among the elderly and when operations are performed by surgeons with very low volumes or in low-volume hospitals. Hospital lengths of stay were shorter and charges were lower when elective AAA repair was performed by surgeons with higher volumes.
随着侵入性较小的修复方法的发展,传统腹主动脉瘤(AAA)修复术的安全性和有效性正受到越来越多的审视。由于大多数已发表的择期AAA修复研究报告的是在三级转诊机构进行的手术,因此可能无法反映整个外科界的手术结果,所以开展了本次基于人群的研究,以记录在特定地理区域广泛的临床实践中所获得的结果,并研究影响手术结果的因素。
使用马里兰州医疗服务成本审查委员会的数据库,确定该州1990年至1995年期间所有非联邦急症医院进行的所有择期AAA修复手术。
该州52家(88%)非联邦急症医院中的46家对2335例患者(平均年龄70.4岁)进行了择期AAA修复手术,其中包括7家高手术量(>100例)、9家中等手术量(50至99例)和30家低手术量(<50例)的机构。住院死亡率为3.5%,并随年龄增长而显著增加:年龄小于65岁者,死亡率为2.2%;65至69岁者,死亡率为2.5%;70至79岁者,死亡率为3.5%;80岁以上者,死亡率为7.3%(P = 0.002)。女性(4.5%对3.2%;P = 0.17)、黑人(6.7%对3.2%;P = 0.046)以及肾衰竭患者(11.8%对3.4%;P = 0.11)的死亡率较高,但高血压、糖尿病、心脏病和肺病患者的死亡率无差异。手术死亡率与医院手术量呈负相关(低手术量医院为4.3%,中等手术量医院为4.2%,高手术量医院为2.5%;P = 0.08),尽管在这三类医院人群中接受手术的患者的平均年龄和合并症水平没有差异。手术死亡率与外科医生个人经验呈负相关:手术1例者,死亡率为9.9%;手术2至9例者,死亡率为4.9%;手术10至49例者,死亡率为2.8%;手术50至99例者,死亡率为2.9%;手术超过100例者,死亡率为3.8%(P = 0.01)。多变量分析结果确定患者年龄(P = 0.002)、医院低手术量(P = 0.039)和外科医生极低手术量(P = 0.01)为手术死亡率的独立预测因素。平均住院时间和平均住院费用分别为10.6天和17,589美元,且随着外科医生手术量的增加而减少:手术1例者,住院时间为22.7天/费用为32,800美元;手术2至9例者,住院时间为10.6天/费用为18,509美元;手术10至49例者,住院时间为10.0天/费用为16,611美元;手术50至99例者,住院时间为10.9天/费用为17,843美元;手术超过100例者,住院时间为9.6天/费用为16,682美元(P < 0.0001/P < 0.0001)。
在马里兰州的当代实践中,择期AAA修复术是一种安全的手术。在老年人以及由手术量极低的外科医生或在低手术量医院进行手术时,手术风险会增加。当由手术量较高的外科医生进行择期AAA修复手术时,住院时间较短且费用较低。