SMAD蛋白降解会关闭信号传导。 - Suppr

Suppr

超能文献

SMAD destruction turns off signalling.

作者信息

Heldin C H, ten Dijke P

出版信息

Nat Cell Biol. 1999 Dec;1(8):E195-7. doi: 10.1038/70223.

DOI:10.1038/70223

PMID:10587654

Abstract

摘要

相似文献

SMAD destruction turns off signalling.

Nat Cell Biol. 1999 Dec;1(8):E195-7. doi: 10.1038/70223.

Ubiquitin-dependent degradation of TGF-beta-activated smad2.

Nat Cell Biol. 1999 Dec;1(8):472-8. doi: 10.1038/70258.

Ubiquitin signalling: what's in a chain?

Nat Cell Biol. 2004 Jul;6(7):571-2. doi: 10.1038/ncb0704-571.

The ubiquitin-proteasome pathway: on protein death and cell life.

EMBO J. 1998 Dec 15;17(24):7151-60. doi: 10.1093/emboj/17.24.7151.

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway.

Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4820-5. doi: 10.1073/pnas.97.9.4820.

The Smad pathway.

Cytokine Growth Factor Rev. 2000 Mar-Jun;11(1-2):5-13. doi: 10.1016/s1359-6101(99)00024-6.

Probing the proteasome pathway.

Nat Biotechnol. 2000 May;18(5):494-6. doi: 10.1038/75349.

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling.

J Biol Chem. 2000 Nov 24;275(47):36818-22. doi: 10.1074/jbc.C000580200.

Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system.

Oncogene. 2000 Apr 13;19(16):1992-2001. doi: 10.1038/sj.onc.1203519.

Tumor viruses and cell signaling pathways: deubiquitination versus ubiquitination.

Mol Cell Biol. 2004 Jun;24(12):5089-93. doi: 10.1128/MCB.24.12.5089-5093.2004.

引用本文的文献

Insulin-like growth factor-binding protein-3 promotes transforming growth factor-{beta}1-mediated epithelial-to-mesenchymal transition and motility in transformed human esophageal cells.

Carcinogenesis. 2010 Aug;31(8):1344-53. doi: 10.1093/carcin/bgq108. Epub 2010 May 31.

Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling.

Oncogene. 2008 Dec 11;27(58):7235-47. doi: 10.1038/onc.2008.337. Epub 2008 Sep 15.

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling.

Genes Dev. 2008 Jan 1;22(1):106-20. doi: 10.1101/gad.1590908.

Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.

Mol Cell Biol. 2000 Dec;20(23):9041-54. doi: 10.1128/MCB.20.23.9041-9054.2000.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验