Al-Awqati Q
Qais Al-Awqati is at the Departments of Medicine and Physiology, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, New York 10032, USA.
Nat Cell Biol. 1999 Dec;1(8):E201-2. doi: 10.1038/70230.
The Overton Rule states that entry of any molecule into a cell is governed by its lipid solubility. Overton's studies led to the hypothesis that cell membranes are composed of lipid domains, which mediate transport of lipophilic molecules, and protein 'pores', which transport hydrophilic molecules. Recent studies, however, have shown that hydrophobic molecules are also transported by families of transporter proteins.
奥弗顿法则指出，任何分子进入细胞都受其脂溶性的支配。奥弗顿的研究提出了一个假说，即细胞膜由脂质区域和蛋白质“孔道”组成，脂质区域介导亲脂性分子的运输，蛋白质“孔道”运输亲水性分子。然而，最近的研究表明，疏水分子也由转运蛋白家族进行运输。
