Ortega E, de Pablo M A, Gallego A M, Gaforio J J, Alvarez C, Ruiz-Bravo A, de Cienfuegos G A
Department of Health Sciences, University of Jaén, Spain.
J Antimicrob Chemother. 1999 Oct;44(4):561-4. doi: 10.1093/jac/44.4.561.
The immunomodulating properties of antimicrobial drugs may have important implications for clinical practice, particularly for those patients whose immune system has been compromised. In this study, we assessed the influence of different treatments with a beta-lactam antibiotic (imipenem/cilastatin) on several acquired immune responses of BALB/c mice; splenocyte responses to specific mitogens and to sheep red blood cells, IL-2 production and proportions of the different lympho-monocytic populations. Impenem/cilastatin was shown to modify some lymphocyte-associated immune functions and it would be useful to investigate whether immunomodulatory effects also occur in humans.
抗菌药物的免疫调节特性可能对临床实践具有重要意义，尤其对于那些免疫系统受损的患者。在本研究中，我们评估了用β-内酰胺类抗生素（亚胺培南/西司他丁）进行不同治疗对BALB/c小鼠几种获得性免疫反应的影响；脾细胞对特定有丝分裂原和绵羊红细胞的反应、白细胞介素-2的产生以及不同淋巴细胞群的比例。结果显示亚胺培南/西司他丁可改变一些与淋巴细胞相关的免疫功能，研究免疫调节作用是否也发生在人类身上将是有益的。
