血液系统肿瘤与中枢神经系统

Hematologic neoplasia and the central nervous system.

作者信息

Sham R L, Phatak P D, Kouides P A, Janas J A, Marder V J

机构信息

Hematology Unit, Department of Medicine, Rochester General Hospital, Rochester, New York 14621, USA.

出版信息

Am J Hematol. 1999 Dec;62(4):234-8. doi: 10.1002/(sici)1096-8652(199912)62:4<234::aid-ajh6>3.0.co;2-b.

DOI:10.1002/(sici)1096-8652(199912)62:4<234::aid-ajh6>3.0.co;2-b

PMID:10589079

Abstract

Central nervous system (CNS) involvement with malignant cells is a well recognized complication of hematologic neoplasms. A number of disorders such as acute lymphoblastic leukemia and high grade lymphoma frequently involve the CNS and prophylactic therapy is advised. Disorders such as acute myeloid leukemia (AML) and multiple myeloma are less likely to be associated with CNS involvement. This series describes three cases of CNS involvement by malignant hematologic disease: myelomatous meningitis, CNS chloromas complicating AML, and primary lymphomatous meningitis.

摘要

中枢神经系统（CNS）受恶性细胞侵犯是血液系统肿瘤一种公认的并发症。许多疾病，如急性淋巴细胞白血病和高级别淋巴瘤，经常侵犯中枢神经系统，因此建议进行预防性治疗。急性髓系白血病（AML）和多发性骨髓瘤等疾病与中枢神经系统受累的关联较小。本系列描述了三例恶性血液病累及中枢神经系统的病例：骨髓瘤性脑膜炎、AML并发的中枢神经系统绿色瘤和原发性淋巴瘤性脑膜炎。