糖肽寡甘露糖核心中依赖生长的改变。
Growth-dependent alterations in oligomannosyl cores of glycopeptides.
作者信息
Ceccarini C, Muramatsu T, Tsang J, Atkinson P H
出版信息
Proc Natl Acad Sci U S A. 1975 Aug;72(8):3139-43. doi: 10.1073/pnas.72.8.3139.
Abstract
Mannose-labeled glycopeptides from the surface of growing and nongrowing human diploid cells (KL-2) were separated into neutral glycopeptides and acidic glycopeptides by paper electrophoresis. Growth-dependent alterations occurred in oligomannosyl cores in the neutral glycopeptides; namely, the neutral glycopeptides from the surface of growing cells were more resistant to endo-beta-N-acetylglucosaminidase D but were more susceptible to alpha-mannosidase (EC 3.2.1.24; alpha-D-mannose mannohydrolase) than those derived from the surface of nongrowing cells. Another growth-dependent change was found when the endoglycosidase-resistant material from acidic glycopeptides was compared by paper electrophoresis at pH 1.9. The material from the surface of nongrowing cells contained a component that was absent or greatly reduced in growing cells.
摘要
通过纸电泳将来自正在生长和未生长的人二倍体细胞（KL-2）表面的甘露糖标记糖肽分离为中性糖肽和酸性糖肽。中性糖肽中的寡甘露糖核心发生了与生长相关的变化；也就是说，来自正在生长细胞表面的中性糖肽比来自未生长细胞表面的中性糖肽对内切β-N-乙酰葡糖胺酶D更具抗性，但对α-甘露糖苷酶（EC 3.2.1.24；α-D-甘露糖甘露水解酶）更敏感。当在pH 1.9条件下通过纸电泳比较酸性糖肽中耐内切糖苷酶的物质时，发现了另一个与生长相关的变化。来自未生长细胞表面的物质含有一种在生长细胞中不存在或大量减少的成分。
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