• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

噬菌体λ中的转录终止与晚期调控。

Transcription termination and late control in phage lambda.

作者信息

Roberts J W

出版信息

Proc Natl Acad Sci U S A. 1975 Sep;72(9):3300-4. doi: 10.1073/pnas.72.9.3300.

DOI:10.1073/pnas.72.9.3300
PMID:1059112
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC432979/
Abstract

A transcription termination site occurs between the promoter for late gene expression of bacteriophage lambda and the late genes themselves. It is proposed that the lambda Q gene product controls late gene expression by over-coming this termination barrier.

摘要

转录终止位点位于噬菌体λ晚期基因表达的启动子与晚期基因本身之间。有人提出，λ Q基因产物通过克服这一终止障碍来控制晚期基因的表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1649/432979/4a38e74b1dcb/pnas00052-0045-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1649/432979/535293c02996/pnas00052-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1649/432979/4a38e74b1dcb/pnas00052-0045-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1649/432979/535293c02996/pnas00052-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1649/432979/4a38e74b1dcb/pnas00052-0045-a.jpg

相似文献

1
Transcription termination and late control in phage lambda.噬菌体λ中的转录终止与晚期调控。
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3300-4. doi: 10.1073/pnas.72.9.3300.
2
Transcription of bacteriophage phi-X174 in vitro: selective initiation with oligonucleotides.
J Mol Biol. 1976 Dec 25;108(4):753-70. doi: 10.1016/s0022-2836(76)80115-5.
3
Regulation of RNA metabolism of T7 and related phages.T7及相关噬菌体的RNA代谢调控
Annu Rev Genet. 1972;6:191-202. doi: 10.1146/annurev.ge.06.120172.001203.
4
Gene Q antiterminator proteins of Escherichia coli phages 82 and lambda suppress pausing by RNA polymerase at a rho-dependent terminator and at other sites.大肠杆菌噬菌体82和λ的基因Q抗终止蛋白可抑制RNA聚合酶在ρ因子依赖性终止子及其他位点处的暂停。
Proc Natl Acad Sci U S A. 1989 Jul;86(14):5301-5. doi: 10.1073/pnas.86.14.5301.
5
Phage lambda gene Q antiterminator recognizes RNA polymerase near the promoter and accelerates it through a pause site.噬菌体λ基因Q抗终止子在启动子附近识别RNA聚合酶，并使其加速通过一个暂停位点。
Cell. 1985 Aug;42(1):259-69. doi: 10.1016/s0092-8674(85)80121-5.
6
Control of gene expression in bacteriophage T7: transcriptional controls.噬菌体T7中的基因表达调控：转录调控
Mol Gen Genet. 1974;134(4):281-97. doi: 10.1007/BF00337463.
7
T7- and T3-specific RNA polymerases: characterization and mapping of the in vitro transcripts read from T3 DNA.T7和T3特异性RNA聚合酶：对从T3 DNA读取的体外转录本的表征与定位
J Virol. 1977 Feb;21(2):743-52. doi: 10.1128/JVI.21.2.743-752.1977.
8
Transcription of the int gene of bacteriophage lambda. New RNA polymerase binding site and RNA start generated by int-constitutive mutations.
J Mol Biol. 1979 Apr 15;129(3):509-14. doi: 10.1016/0022-2836(79)90510-2.
9
In vitro system for induction of delayed early RNA of bacteriophage T4.用于诱导噬菌体T4延迟早期RNA的体外系统。
Proc Natl Acad Sci U S A. 1976 Aug;73(8):2569-73. doi: 10.1073/pnas.73.8.2569.
10
Determination of genes, restriction sites, and DNA sequences surrounding the 6S RNA template of bacteriophage lambda.噬菌体λ 6S RNA模板周围基因、限制酶切位点及DNA序列的测定
Proc Natl Acad Sci U S A. 1975 May;72(5):1817-21. doi: 10.1073/pnas.72.5.1817.

引用本文的文献

1
Excess A-subunits of Shiga toxin 2a are produced in enterohemorrhagic Escherichia coli.志贺毒素2a的A亚基过量产生于肠出血性大肠杆菌中。
Sci Rep. 2025 May 14;15(1):16712. doi: 10.1038/s41598-025-01342-2.
2
Structural basis of transcriptional regulation by a nascent RNA element, HK022 putRNA.新生 RNA 元件 HK022 putRNA 转录调控的结构基础。
Nat Commun. 2022 Aug 15;13(1):4668. doi: 10.1038/s41467-022-32315-y.
3
In transcription antitermination by Qλ, NusA induces refolding of Qλ to form a nozzle that extends the RNA polymerase RNA-exit channel.

本文引用的文献

1
Promoter mutation in vitro.体外启动子突变
Nature. 1969 Aug 2;223(5205):480-2. doi: 10.1038/223480a0.
2
A site essential for expression of all late genes in bacteriophage lambda.噬菌体λ中所有晚期基因表达所必需的一个位点。
J Mol Biol. 1970 Feb 14;47(3):545-56. doi: 10.1016/0022-2836(70)90321-9.
3
Studies of novel transducing variants of lambda: dispensability of genes N and Q.λ新型转导变体的研究：基因N和Q的非必需性
在 Qλ的转录反终止中，NusA 诱导 Qλ 重新折叠形成一个喷口，从而延伸 RNA 聚合酶的 RNA 出口通道。
Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2205278119. doi: 10.1073/pnas.2205278119. Epub 2022 Aug 11.
4
Early termination of the Shiga toxin transcript generates a regulatory small RNA.志贺毒素转录本的早期终止产生一种调控小 RNA。
Proc Natl Acad Sci U S A. 2020 Oct 6;117(40):25055-25065. doi: 10.1073/pnas.2006730117. Epub 2020 Sep 23.
5
Structural basis of Q-dependent antitermination.Q 依赖性终止抑制的结构基础。
Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18384-18390. doi: 10.1073/pnas.1909801116. Epub 2019 Aug 27.
6
Expression of Mycobacteriophage Ms6 lysis genes is driven by two sigma(70)-like promoters and is dependent on a transcription termination signal present in the leader RNA.分枝杆菌噬菌体Ms6裂解基因的表达由两个类σ⁷⁰启动子驱动，并且依赖于前导RNA中存在的转录终止信号。
J Bacteriol. 2002 Jun;184(11):3034-43. doi: 10.1128/JB.184.11.3034-3043.2002.
7
S gene expression and the timing of lysis by bacteriophage lambda.噬菌体λ的S基因表达与裂解时间
J Bacteriol. 1995 Jun;177(11):3283-94. doi: 10.1128/jb.177.11.3283-3294.1995.
8
Monocistronic and polycistronic bacteriophage T4 gene 23 messages.单顺反子和多顺反子噬菌体T4基因23信使RNA。
J Virol. 1981 Dec;40(3):790-9. doi: 10.1128/JVI.40.3.790-799.1981.
9
Regulation of early adenovirus transcription: a protein product of early region 2 specifically represses region 4 transcription.早期腺病毒转录的调控：早期区域2的一种蛋白质产物特异性抑制区域4的转录。
Proc Natl Acad Sci U S A. 1980 Apr;77(4):1893-7. doi: 10.1073/pnas.77.4.1893.
10
Shutoff of lambda gene expression by bacteriophage T4: role of the T4 alc gene.噬菌体T4对λ基因表达的关闭：T4 alc基因的作用
J Virol. 1980 Jul;35(1):194-202. doi: 10.1128/JVI.35.1.194-202.1980.
Virology. 1969 Oct;39(2):348-52. doi: 10.1016/0042-6822(69)90060-9.
4
Nucleotide sequence of a ribonucleic acid transcribed in vitro from lambda phage deoxyribonucleic acid.从λ噬菌体脱氧核糖核酸体外转录的核糖核酸的核苷酸序列。
J Biol Chem. 1971 Aug 25;246(16):5120-39.
5
Dual control of arabinose genes on transducing phage lambda-dara.转导噬菌体λ-dara上阿拉伯糖基因的双重控制
J Mol Biol. 1971 Jul 14;59(1):127-50. doi: 10.1016/0022-2836(71)90417-7.
6
[Physiological relationship between the temperate phages lambda and phi80].[温和噬菌体λ与φ80之间的生理关系]
Mol Gen Genet. 1970;108(1):78-92. doi: 10.1007/BF00343187.
7
Termination factor for RNA synthesis.RNA合成的终止因子。
Nature. 1969 Dec 20;224(5225):1168-74. doi: 10.1038/2241168a0.
8
Molecular weight estimation and separation of ribonucleic acid by electrophoresis in agarose-acrylamide composite gels.在琼脂糖-丙烯酰胺复合凝胶中通过电泳进行核糖核酸的分子量估计及分离
Biochemistry. 1968 Feb;7(2):668-74. doi: 10.1021/bi00842a023.
9
Gene N regulator function of phage lambda immun21: evidence that a site of N action differs from a site of N recognition.噬菌体λ免疫21的基因N调节功能：N作用位点与N识别位点不同的证据。
J Mol Biol. 1973 Dec 25;81(4):505-16. doi: 10.1016/0022-2836(73)90519-6.
10
Analysis of bacteriophage T7 early RNAs and proteins on slab gels.平板凝胶上噬菌体T7早期RNA和蛋白质的分析。
J Mol Biol. 1973 Sep 15;79(2):237-48. doi: 10.1016/0022-2836(73)90003-x.