Kanehisa M, Goto S
Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.
Nucleic Acids Res. 2000 Jan 1;28(1):27-30. doi: 10.1093/nar/28.1.27.
KEGG (Kyoto Encyclopedia of Genes and Genomes) is a knowledge base for systematic analysis of gene functions, linking genomic information with higher order functional information. The genomic information is stored in the GENES database, which is a collection of gene catalogs for all the completely sequenced genomes and some partial genomes with up-to-date annotation of gene functions. The higher order functional information is stored in the PATHWAY database, which contains graphical representations of cellular processes, such as metabolism, membrane transport, signal transduction and cell cycle. The PATHWAY database is supplemented by a set of ortholog group tables for the information about conserved subpathways (pathway motifs), which are often encoded by positionally coupled genes on the chromosome and which are especially useful in predicting gene functions. A third database in KEGG is LIGAND for the information about chemical compounds, enzyme molecules and enzymatic reactions. KEGG provides Java graphics tools for browsing genome maps, comparing two genome maps and manipulating expression maps, as well as computational tools for sequence comparison, graph comparison and path computation. The KEGG databases are daily updated and made freely available (http://www. genome.ad.jp/kegg/).
京都基因与基因组百科全书（KEGG）是一个用于基因功能系统分析的知识库，它将基因组信息与高阶功能信息联系起来。基因组信息存储在GENES数据库中，该数据库是所有已完成全序列测定的基因组以及一些具有最新基因功能注释的部分基因组的基因目录集合。高阶功能信息存储在PATHWAY数据库中，该数据库包含细胞过程的图形表示，如代谢、膜转运、信号转导和细胞周期。PATHWAY数据库由一组直系同源基团表补充，用于提供关于保守子途径（途径基序）的信息，这些子途径通常由染色体上位置耦合的基因编码，在预测基因功能方面特别有用。KEGG中的第三个数据库是LIGAND，用于提供关于化合物、酶分子和酶促反应的信息。KEGG提供了用于浏览基因组图谱、比较两个基因组图谱和操作表达图谱的Java图形工具，以及用于序列比较、图形比较和路径计算的计算工具。KEGG数据库每日更新并免费提供（http://www.genome.ad.jp/kegg/）。
