Bairoch A, Apweiler R
Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland.
Nucleic Acids Res. 2000 Jan 1;28(1):45-8. doi: 10.1093/nar/28.1.45.
SWISS-PROT is a curated protein sequence database which strives to provide a high level of annotation (such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc.), a minimal level of redundancy and high level of integration with other databases. Recent developments of the database include format and content enhancements, cross-references to additional databases, new documentation files and improvements to TrEMBL, a computer-annotated supplement to SWISS-PROT. TrEMBL consists of entries in SWISS-PROT-like format derived from the translation of all coding sequences (CDSs) in the EMBL Nucleotide Sequence Database, except the CDSs already included in SWISS-PROT. We also describe the Human Proteomics Initiative (HPI), a major project to annotate all known human sequences according to the quality standards of SWISS-PROT. SWISS-PROT is available at: http://www.expasy.ch/sprot/ and http://www.ebi.ac.uk/swissprot/
SWISS-PROT是一个经过精心整理的蛋白质序列数据库,致力于提供高水平的注释(如蛋白质功能描述、结构域结构、翻译后修饰、变体等),冗余度降至最低,并与其他数据库高度整合。该数据库的最新进展包括格式和内容的改进、与其他数据库的交叉引用、新的文档文件以及对TrEMBL(SWISS-PROT的计算机注释补充数据库)的改进。TrEMBL由从EMBL核苷酸序列数据库中所有编码序列(CDS)翻译而来的类似SWISS-PROT格式的条目组成,但不包括已包含在SWISS-PROT中的CDS。我们还描述了人类蛋白质组计划(HPI),这是一个根据SWISS-PROT的质量标准注释所有已知人类序列的重大项目。可通过以下网址访问SWISS-PROT:http://www.expasy.ch/sprot/ 以及http://www.ebi.ac.uk/swissprot/