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丙烯酰胺神经病变中的肝脏UDP-葡萄糖醛酸基转移酶活性

Hepatic UDP-glucuronyltransferase activity in acrylamide neuropathy.

作者信息

Howland R D, Lowndes H E

出版信息

Experientia. 1979 Feb 15;35(2):248-9. doi: 10.1007/BF01920644.

DOI:10.1007/BF01920644
PMID:105928
Abstract

Acrylamide was found to be tissue selective in its toxicity. Doses which were clearly neurotoxic to rats were without effect on hepatic UDP-glucuronyltransferase, total hepatic protein or microsomal protein.

摘要

已发现丙烯酰胺具有组织选择性毒性。对大鼠具有明显神经毒性的剂量对肝脏UDP-葡萄糖醛酸基转移酶、肝脏总蛋白或微粒体蛋白没有影响。

相似文献

1
Hepatic UDP-glucuronyltransferase activity in acrylamide neuropathy.丙烯酰胺神经病变中的肝脏UDP-葡萄糖醛酸基转移酶活性
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2
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9
Metabolic interaction and neurological effect of combined exposure to acrylamide and ethanol.
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Immunochemical comparison of UDP-glucuronyltransferase from Gunn- and Wistar-rat livers.冈恩大鼠和Wistar大鼠肝脏中UDP-葡萄糖醛酸基转移酶的免疫化学比较。
Biochem J. 1980 Oct 1;191(1):155-63. doi: 10.1042/bj1910155.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Biochemical studies on acrylamide, a neurotoxic agent.对神经毒性剂丙烯酰胺的生化研究。
Biochem Pharmacol. 1970 Sep;19(9):2591-604. doi: 10.1016/0006-2952(70)90009-2.
3
The pathogenesis of dying-back polyneuropathies. II. An ultrastructural study of experimental acrylamide intoxication in the cat.逆行性多神经病的发病机制。II. 猫实验性丙烯酰胺中毒的超微结构研究。
J Neuropathol Exp Neurol. 1969 Oct;28(4):598-621. doi: 10.1097/00005072-196910000-00004.
4
The effects of sulfhydryl reacting agents on hepatic UDP-glucuronyltransferase in vitro.巯基反应剂对体外肝脏UDP-葡萄糖醛酸基转移酶的影响。
Biochim Biophys Acta. 1971 Sep 22;242(3):549-59. doi: 10.1016/0005-2744(71)90148-3.
5
Regulation of microsomal enzymes by phospholipids. IV. Species differences in the properties of microsomal UDP-glucuronyltransferase.磷脂对微粒体酶的调节作用。IV. 微粒体UDP-葡萄糖醛酸基转移酶性质的种属差异
Biochim Biophys Acta. 1972 Apr 7;268(1):61-9. doi: 10.1016/0005-2744(72)90197-0.
6
Vincristine-induced axonal alterations in rat peripheral nerve.
J Neuropathol Exp Neurol. 1971 Jul;30(3):488-505. doi: 10.1097/00005072-197107000-00012.
7
Alteration of amino acid incorporation into proteins of the nervous system in vitro after administration of acrylamide to rats.
Biochem Pharmacol. 1973 May 1;22(9):1057-66. doi: 10.1016/0006-2952(73)90170-6.
8
Studies on drug-induced neuropathies. III. Motor nerve deficit in cats with experimental acrylamide neuropathy.
Eur J Pharmacol. 1976 Jan;35(1):177-84. doi: 10.1016/0014-2999(76)90313-7.
9
The distribution and metabolism of acrylamide and its neurotoxic analogues in rats.
Biochem Pharmacol. 1975 Jul 15;24(13-14):1277-82. doi: 10.1016/0006-2952(75)90336-6.
10
Commentary: Control of UDP-glucuronyltransferase activity.
Biochem Pharmacol. 1975 Oct 15;24(20):1835-41. doi: 10.1016/0006-2952(75)90399-8.