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儿童与成人急性髓细胞白血病的比较研究。

A comparative study of acute myeloblastic leukaemia in children and adults.

作者信息

Ansari B M, Thompson E N, Whittaker J A

出版信息

Br J Haematol. 1975 Nov;31(3):269-77. doi: 10.1111/j.1365-2141.1975.tb00858.x.

DOI:10.1111/j.1365-2141.1975.tb00858.x
PMID:1059477
Abstract

The presenting features and clinical course of 89 adults and 15 children with acute myeloblastic leukaemia (AML) presenting to a Regional Leukaemia Centre has been analysed. Remission rate was related to age, being 40% for the total adult group and 60% for all children. Young adults and children had a particularly high remission rate, whilst elderly patients faired badly. Survival diminished with increasing age and patients who entered complete remission survived for a significantly longer time (P less than 0.001) than those who did not. Adult AML differs from childhood AML, the adults having a lower remission rate, a significantly shorter survival (P less than 0.005) and almost complete absence of second remissions. Adults showed no correlation between complete remission and initial WBC or initial blast cell count, but in children there was a significant correlation (P less than 0.05) between initial total WBC and complete remission. A significant correlation between initial platelet count and complete remission could not be demonstrated in either group. Although the numbers of children are small, preadolescent children may represent a favourable sub-group, particularly those between 7 and 8 years of age.

摘要

对一家地区白血病中心收治的89名成人和15名儿童急性髓细胞白血病(AML)患者的临床表现和病程进行了分析。缓解率与年龄有关,成年组总体缓解率为40%,儿童为60%。年轻成人和儿童的缓解率特别高,而老年患者情况较差。生存率随年龄增长而降低,进入完全缓解的患者存活时间明显长于未进入完全缓解的患者(P<0.001)。成人AML与儿童AML不同,成人缓解率较低,生存时间显著缩短(P<0.005),几乎没有二次缓解。成人组完全缓解与初始白细胞计数或原始细胞计数之间无相关性,但儿童组初始白细胞总数与完全缓解之间存在显著相关性(P<0.05)。两组中均未发现初始血小板计数与完全缓解之间存在显著相关性。尽管儿童数量较少,但青春期前儿童可能是一个预后良好的亚组,尤其是7至8岁的儿童。

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Br Med J. 1979 Jan 27;1(6158):227-9. doi: 10.1136/bmj.1.6158.227.