The pharmacological effects of an aqueous extract from Acacia nilotica seeds.

作者信息

Amos S, Akah P A, Odukwe C J, Gamaniel K S, Wambede C

机构信息

Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, P. M. B. 21, Abuja, Nigeria.

出版信息

Phytother Res. 1999 Dec;13(8):683-5. doi: 10.1002/(sici)1099-1573(199912)13:8<683::aid-ptr534>3.0.co;2-x.

DOI:10.1002/(sici)1099-1573(199912)13:8<683::aid-ptr534>3.0.co;2-x

PMID:10594939

Abstract

An aqueous extract of the seed of Acacia nilotica was investigated for its pharmacological profile. On the isolated guinea-pig ileum, the extract displayed sustained dose-related contractile activity. The contractions which were reduced by hexamethonium, promethazine or atropine were completely abolished by nifedipine. The intravenous (i.v.) administration of the extract (11, 22, 44, 55 microg/kg) to anaesthetized cats produced a dose-related significant elevation of blood pressure. The mechanisms of the spasmogenic and vasoconstrictor actions of the extract have not been determined, however, the results suggest the involvement of calcium.

摘要