阿尔卑斯球花报春提取物在体外可降低组胺和血清素引起的收缩反应。
Globularia alypum L. extracts reduced histamine and serotonin contraction in vitro.
作者信息
Bello Regina, Moreno Lucrecia, Primo-Yúfera Eduardo, Esplugues Juan
机构信息
Departamento de Farmacología, Facultad de Medicina y Odontología, Universidad de Valencia, Av. Blasco Ibañez 17, 46010 Valencia, Spain.
出版信息
Phytother Res. 2002 Jun;16(4):389-92. doi: 10.1002/ptr.918.
The present study analyses in in vitro models the pharmacological activity of methanol and dichloromethane extracts (1, 10 and 100 microg/mL) obtained from the leaves and stems of Globularia alypum L. Preincubation of the guinea-pig ileum and rat uterus with both extracts produced a dose dependent abolition of the contractile effects of histamine and serotonin, respectively. At the same doses, neither methanol nor dichloromethane extract reduced the contractile effects of acetylcholine on rat duodenum or noradrenaline on rat vas deferens.
本研究在体外模型中分析了从刺球果叶和茎中获得的甲醇提取物和二氯甲烷提取物（1、10和100微克/毫升）的药理活性。用这两种提取物对豚鼠回肠和大鼠子宫进行预孵育，分别产生了剂量依赖性地消除组胺和5-羟色胺收缩作用的效果。在相同剂量下，甲醇提取物和二氯甲烷提取物均未降低乙酰胆碱对大鼠十二指肠或去甲肾上腺素对大鼠输精管的收缩作用。
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