Nishimura H, Tsuji H, Masuda H, Kasahara T, Yoshizumi M, Sugano T, Kimura S, Kawano H, Kunieda Y, Yano S, Nakagawa K, Kitamura H, Nakahara Y, Sawada S, Nakagawa M
Second Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Japan.
Thromb Haemost. 1999 Nov;82(5):1516-21.
Not only angiotensin II (Ang II) but also other angiotensin metabolites such as angiotensin I (Ang I), angiotensin III (Ang III), angiotensin IV, or angiotensin 1-7 have recently been reported to have various activities. Few data, however, are available on the regulation of thrombus formation. In this study, we investigated the effects of angiotensin metabolites on the mRNA expression of tissue factor (TF), tissue factor pathway inhibitor (TFPI), plasminogen activator inhibitor-1 (PAI-1), and tissue type plasminogen activator (TPA) in cultured rat aortic endothelial cells. None of the used angiotensin metabolites altered TFPI or TPA mRNA expression levels. Ang I, Ang II, and Ang III made TF and PAI-1 mRNA inductions which were inhibited by an selective antagonist of angiotensin II type 1 receptors. These metabolites made TF predominant to TFPI or PAI-1 to TPA, and could render endothelial cells thrombogenic.
最近有报道称，不仅血管紧张素II（Ang II），而且其他血管紧张素代谢产物，如血管紧张素I（Ang I）、血管紧张素III（Ang III）、血管紧张素IV或血管紧张素1-7都具有多种活性。然而，关于血栓形成调节的资料却很少。在本研究中，我们调查了血管紧张素代谢产物对培养的大鼠主动脉内皮细胞中组织因子（TF）、组织因子途径抑制物（TFPI）、纤溶酶原激活物抑制剂-1（PAI-1）和组织型纤溶酶原激活物（TPA）mRNA表达的影响。所使用的血管紧张素代谢产物均未改变TFPI或TPA的mRNA表达水平。Ang I、Ang II和Ang III可诱导TF和PAI-1的mRNA表达，而血管紧张素II 1型受体的选择性拮抗剂可抑制这种诱导作用。这些代谢产物使TF相对于TFPI占优势，或使PAI-1相对于TPA占优势，并可使内皮细胞具有血栓形成倾向。
