Ferrario Carlos M, Ahmad Sarfaraz, Joyner Janae, Varagic Jasmina
Hypertension and Vascular Disease Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA;.
Adv Pharmacol. 2010;59:197-233. doi: 10.1016/S1054-3589(10)59007-0.
The contribution of the renin angiotensin system to physiology and pathology is undergoing a rapid reconsideration of its mechanisms from emerging new concepts implicating angiotensin-converting enzyme 2 and angiotensin-(1-7) as new elements negatively influencing the vasoconstrictor, trophic, and pro-inflammatory actions of angiotensin II. This component of the system acts to oppose the vasoconstrictor and proliferative effects on angiotensin II through signaling mechanisms mediated by the mas receptor. In addition, a reduced expression of the vasodepressor axis composed by angiotensin-converting enzyme 2 and angiotensin-(1-7) may contribute to the expression of essential hypertension, the remodeling of heart and renal function associated with this disease, and even the physiology of pregnancy and the development of eclampsia.
肾素血管紧张素系统对生理和病理的作用正在经历机制上的快速重新审视，这源于新出现的概念，即血管紧张素转换酶2和血管紧张素-（1-7）作为新元素，对血管紧张素II的血管收缩、营养和促炎作用产生负面影响。该系统的这一组成部分通过mas受体介导的信号机制，对抗血管紧张素II的血管收缩和增殖作用。此外，由血管紧张素转换酶2和血管紧张素-（1-7）组成的血管舒张轴表达降低，可能导致原发性高血压的发生、与该疾病相关的心脏和肾功能重塑，甚至影响妊娠生理和子痫的发展。
