Carr J A, Silverman N
Division of Cardiac and Thoracic Surgery, Henry Ford Hospital, Detroit, MI 48202, USA.
J Cardiovasc Surg (Torino). 1999 Oct;40(5):659-66.
The heparin-protamine interaction is a topic of intense scrutiny due to its mandatory use during cardiopulmonary bypass. It can be estimated that over 2,000,000 patients are exposed to the heparin-protamine interaction each year. From clinical and experimental observation it is known that protamine neutralization of heparin causes increased pulmonary artery pressures and decreased systolic and diastolic blood pressure, myocardial oxygen consumption, cardiac output, heart rate, and systemic vascular resistance. These multiple cardiovascular effects are mediated via complement activation, histamine release, thromboxane and nitric oxide production, and antibody formation. This article reviews the current understanding of the heparin-protamine interaction from the world's literature.
由于在体外循环期间肝素-鱼精蛋白相互作用是必须发生的，因此它是一个受到密切关注的话题。据估计，每年有超过200万患者会经历肝素-鱼精蛋白相互作用。从临床和实验观察中可知，鱼精蛋白中和肝素会导致肺动脉压力升高，收缩压和舒张压降低，心肌耗氧量、心输出量、心率以及全身血管阻力下降。这些多种心血管效应是通过补体激活、组胺释放、血栓素和一氧化氮生成以及抗体形成介导的。本文综述了从世界文献中对肝素-鱼精蛋白相互作用的当前认识。
