Abe K, Sakakibara T, Miyamoto Y, Ohnishi K
Department of Anaesthesiology, Osaka University Medical School, Suita, Japan.
Eur J Clin Pharmacol. 1998 Mar;54(1):21-5. doi: 10.1007/s002280050414.
The effects of prostaglandin E1 on pulmonary hypertension were assessed after protamine injection at the end of cardiopulmonary bypass during cardiac surgery.
Ten patients scheduled for cardiac surgery presented with pulmonary hypertension (mean pulmonary artery pressure greater than 30 mmHg) after protamine injection and were treated by infusion of 0.02 microg x kg(-1) x min(-1) prostaglandin E1. Hemodynamic measurements were made on occasions after cardiopulmonary bypass. Prostaglandin E1 decreased pulmonary artery pressure, pulmonary vascular resistance, right ventricular stroke work index and pulmonary vascular resistance/systemic vascular resistance ratio, but did not change blood pressure, systemic vascular resistance, left ventricular stroke work index or cardiac output.
Prostaglandin E1 normalized pulmonary hypertension after protamine injection, but did not change arterial blood pressure and cardiac output.
在心脏手术体外循环结束时注射鱼精蛋白后，评估前列腺素E1对肺动脉高压的影响。
10例计划进行心脏手术的患者在注射鱼精蛋白后出现肺动脉高压（平均肺动脉压大于30 mmHg），并接受0.02μg·kg⁻¹·min⁻¹前列腺素E1静脉输注治疗。在体外循环后不同时间点进行血流动力学测量。前列腺素E1降低了肺动脉压、肺血管阻力、右心室每搏功指数和肺血管阻力/体循环血管阻力比值，但未改变血压、体循环血管阻力、左心室每搏功指数或心输出量。
前列腺素E1可使注射鱼精蛋白后的肺动脉高压恢复正常，但不改变动脉血压和心输出量。
