Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.
Int J Clin Pract. 2022 Jul 9;2022:2226761. doi: 10.1155/2022/2226761. eCollection 2022.
The databases of PubMed, Scopus, Embase, and Web of Science were searched systematically up to November 2021. The quality of RCTs was assessed by Cochrane Collaboration's tool and the risk of bias was assessed for cohort studies through NOS score.
Out of 3288 articles, eight studies were eligible to be included in this study. Our review retrieved six RCTs and two retrospective cohort studies consisting of 950 participants diagnosed by DIC. A significant effect of heparin on DIC mortality was identified in four studies. Furthermore, heparin was used as a control group in three studies.
We concluded that administration of heparin and its preparations in DIC patients could reduce the mortality rate and duration of hospitalization, especially in the earlier stages of DIC.
系统检索了 PubMed、Scopus、Embase 和 Web of Science 数据库，截至 2021 年 11 月。使用 Cochrane 协作工具评估 RCT 的质量，使用 NOS 评分评估队列研究的偏倚风险。
在 3288 篇文章中，有 8 篇研究符合纳入标准。我们的综述检索到 6 项 RCT 和 2 项回顾性队列研究，共纳入 950 例 DIC 患者。四项研究表明肝素对 DIC 死亡率有显著影响。此外，肝素在三项研究中被用作对照组。
我们的结论是，在 DIC 患者中使用肝素及其制剂可以降低死亡率和住院时间，尤其是在 DIC 的早期阶段。
