George V, Tiwari H K, Shu Y, Zhu X, Elston R C
Division of Biostatistics, Medical College of Wisconsin, Milwaukee 53226, USA.
Genet Epidemiol. 1999;17 Suppl 1:S157-61. doi: 10.1002/gepi.1370170727.
Recently, George et al. proposed a regression-based transmission/disequilibrium test for linkage using information on the parent-to-offspring transmission status of an allele at a marker locus. We extended this test by simultaneously testing for any population association by incorporating the presence/absence status of the associated allele as a covariate in the model. We used this method to analyze markers on chromosomes 1 through 21 of the Collaborative Study on the Genetics of Alcoholism data on alcoholism for possible association and linkage. We found nominal significance (at the 0.02 level) at eight different regions for linkage, though statistical significance may not be concluded due to multiple testing. The strongest evidence of linkage was observed for markers D4S2639 and D12S397 with p-values less than 0.005. We also found strong association between the trait and alleles 149 of D7S691 and 131 of D21S1437.
最近，乔治等人提出了一种基于回归的传递/不平衡检验用于连锁分析，该检验利用标记位点上等位基因的亲代到子代传递状态信息。我们通过在模型中纳入相关等位基因的存在/缺失状态作为协变量，同时检验任何群体关联，对该检验进行了扩展。我们使用这种方法分析了酒精中毒遗传学合作研究中1号至21号染色体上的标记，以寻找与酒精中毒可能的关联和连锁。我们在八个不同区域发现了名义上的显著性（在0.02水平）用于连锁分析，不过由于多重检验，可能无法得出统计学显著性。对于标记D4S2639和D12S397，观察到了最强的连锁证据，其p值小于0.005。我们还发现该性状与D7S691的149等位基因和D21S1437的131等位基因之间存在强关联。
