National Human Genome Center, Howard University, Washington, DC 20059-0001, USA.
BMC Genet. 2005 Dec 30;6 Suppl 1(Suppl 1):S119. doi: 10.1186/1471-2156-6-S1-S119.
A genetic analysis of age of onset of alcoholism was performed on the Collaborative Study on the Genetics of Alcoholism data released for Genetic Analysis Workshop 14. Our study illustrates an application of the log-normal age of onset model in our software Genetic Epidemiology Models (GEMs). The phenotype ALDX1 of alcoholism was studied. The analysis strategy was to first find the markers of the Affymetrix SNP dataset with significant association with age of onset, and then to perform linkage analysis on them. ALDX1 revealed strong evidence of linkage for marker tsc0041591 on chromosome 2 and suggestive linkage for marker tsc0894042 on chromosome 3. The largest separation in mean ages of onset of ALDX1 was 19.76 and 24.41 between male smokers who are carriers of the risk allele of tsc0041591 and the non-carriers, respectively. Hence, male smokers who are carriers of marker tsc0041591 on chromosome 2 have an average onset of ALDX1 almost 5 years earlier than non-carriers.
我们对为遗传分析研讨会 14 发布的酒精中毒发病年龄的协作研究数据进行了遗传分析。我们的研究说明了对数正态发病年龄模型在我们的软件遗传流行病学模型（GEMs）中的应用。研究了酒精中毒的表型 ALDX1。分析策略是首先找到与发病年龄有显著关联的 Affymetrix SNP 数据集的标记，然后对其进行连锁分析。ALDX1 显示标记 tsc0041591 位于 2 号染色体上具有强烈的连锁证据，标记 tsc0894042 位于 3 号染色体上具有提示性连锁。携带风险等位基因 tsc0041591 的男性吸烟者与非携带者的 ALDX1 发病年龄平均值相差 19.76 和 24.41 岁。因此，携带 2 号染色体上标记 tsc0041591 的男性吸烟者的 ALDX1 发病平均年龄比非携带者早近 5 年。
