Ohno S
Beckman Research Institute of the City of Hope, Duarte, CA 91010-3000, USA.
Semin Cell Dev Biol. 1999 Oct;10(5):517-22. doi: 10.1006/scdb.1999.0332.
In this article I review research undertaken over the past 30 years into the role that gene duplication played in shaping vertebrate genomes. I discuss early karyotype studies that pointed to a relative stability of mammalian and avian genomes, the discovery and possible evolutionary significance of enormous genomes in urodele amphibians and lungfish, genome compaction in certain specialised bony fish, evidence for two rounds of total genome doubling in early vertebrate evolution and the fate of duplicated genes in polyploid fish.
在本文中，我回顾了过去30年里关于基因复制在塑造脊椎动物基因组中所起作用的研究。我讨论了早期的核型研究，这些研究指出哺乳动物和鸟类基因组具有相对稳定性；有尾两栖动物和肺鱼巨大基因组的发现及其可能的进化意义；某些特化硬骨鱼的基因组压缩；早期脊椎动物进化过程中两轮全基因组加倍的证据；以及多倍体鱼类中重复基因的命运。
