Uterine pleomorphic rhabdomyosarcoma in a patient receiving tamoxifen therapy.

INTRODUCTION

Tamoxifen has been used as adjuvant therapy for the treatment of breast cancer. Its use has been associated with the development of proliferative endometrial lesions such as polyps, hyperplasia, and carcinoma. Mesenchymal tumors including malignant mixed mullerian tumors, endometrial stromal sarcomas, adenosarcomas, and leiomyosarcomas have been more recently described with tamoxifen use.

CASE REPORT

This report describes the first case of a pure uterine rhabdomyosarcoma in a patient receiving tamoxifen therapy.

DISCUSSION

Although uterine rhabdomyosarcomas are rare tumors and may arise de novo, we discuss the possible role of tamoxifen in the development of these mesenchymal tumors.