Royackkers N, Desvignes M, Fawal H, Revenu M
GREYC-ISMRA (UPRESA CNRS 6072), 6, Boulevard Maréchal Juin, Caen Cedex, 14050, France.
Neuroimage. 1999 Dec;10(6):625-41. doi: 10.1006/nimg.1999.0512.
Many studies dealing with the human brain use the spatial coordinate system of brain anatomy to localize functional regions. Unfortunately, brain anatomy, and especially cortical sulci, is characterized by a high interindividual variability. Specific tools called anatomical atlases must then be considered to make the interpretation of anatomical examinations easier. The work described here first aims at building a numerical atlas of the main cortical sulci. Our system is based on a database containing a collection of anatomical MRI of healthy volunteer brains. Their sulci have been manually drawn and labeled for both hemispheres. Sulci are represented as 3D superficial curves. After a nonlinear registration process, a statistical atlas of the cortical topography of a particular MRI is built from the database. It is an a priori model of cortical sulci, including three major components: an average curve represents the average shape and position of each sulcus; a search area accounts for its spatial variation domain; a set of quantitative parameters describes the variability of sulci geometry and topology. This atlas is completely individualized and adapted to the features of the brain under examination. The atlas is represented by a graph, the nodes of which represent sulci and the edges the relations between sulci. It can also be considered a statistical model that describes the cortical topography as well as its variability.
许多关于人类大脑的研究使用脑解剖学的空间坐标系来定位功能区域。不幸的是，脑解剖结构，尤其是皮质沟，具有高度的个体间差异。因此，必须考虑使用称为解剖图谱的特定工具，以便更轻松地解释解剖学检查结果。本文所述的工作首先旨在构建一个主要皮质沟的数字图谱。我们的系统基于一个数据库，该数据库包含一组健康志愿者大脑的解剖学磁共振成像（MRI）。他们的脑沟已针对两个半球进行了手动绘制和标记。脑沟被表示为三维表面曲线。经过非线性配准过程后，从数据库中构建特定MRI的皮质地形统计图谱。它是皮质沟的先验模型，包括三个主要组成部分：一条平均曲线表示每个脑沟的平均形状和位置；一个搜索区域说明了其空间变化范围；一组定量参数描述了脑沟几何形状和拓扑结构的变异性。这个图谱是完全个性化的，并适应所检查大脑的特征。该图谱由一个图形表示，其节点代表脑沟，边代表脑沟之间的关系。它也可以被视为一个统计模型，用于描述皮质地形及其变异性。
