Repa J J, Mangelsdorf D J
Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75235-9050, USA.
Curr Opin Biotechnol. 1999 Dec;10(6):557-63. doi: 10.1016/s0958-1669(99)00031-2.
The metabolism of cholesterol and bile acids is transcriptionally regulated by classic feedforward and feedback signaling pathways. The mechanisms underlying this regulation have recently been elucidated by the characterization of three classes of orphan nuclear receptors. Furthermore, the study of these receptors suggests their potential as targets for new drug therapies.
胆固醇和胆汁酸的代谢受经典前馈和反馈信号通路的转录调控。最近，通过对三类孤儿核受体的特性研究，阐明了这种调控的潜在机制。此外，对这些受体的研究表明它们有望成为新药治疗的靶点。
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