McCafferty D G, Cudic P, Yu M K, Behenna D C, Kruger R
Department of Biochemistry and Biophysics, Johnson Research Foundation, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6059, USA.
Curr Opin Chem Biol. 1999 Dec;3(6):672-80. doi: 10.1016/s1367-5931(99)00025-3.
The molecular mechanisms by which peptide antibiotics disrupt bacterial DNA synthesis, protein biosynthesis, cell wall biosynthesis, and membrane integrity are diverse, yet historically have been understood to follow a theme of one antibiotic, one inhibitory mechanism. In the past year, mechanistic and structural studies have shown a rich diversity in peptide antibiotic mechanism. Novel secondary targeting mechanisms for peptide antibiotics have recently been discovered, and the mechanisms of peptide antibiotics involved in synergistic relationships with antibiotics and proteins have been more clearly defined. In apparent response to selective pressures, antibiotic-producing organisms have elegantly integrated multiple functions and cooperative interactions into peptide antibiotic design for the purpose of improving antimicrobial success.
肽类抗生素破坏细菌DNA合成、蛋白质生物合成、细胞壁生物合成及膜完整性的分子机制多种多样，但从历史上看，人们一直认为遵循一种抗生素、一种抑制机制的模式。在过去一年里，机理和结构研究表明肽类抗生素的作用机制具有丰富的多样性。最近发现了肽类抗生素的新型二级靶向机制，并且与抗生素和蛋白质协同关系中涉及的肽类抗生素机制也得到了更明确的界定。显然是为了应对选择性压力，抗生素产生菌已巧妙地将多种功能和协同相互作用整合到肽类抗生素设计中，以提高抗菌成效。
