实验性小鼠布鲁氏菌病期间巨噬细胞的激活：慢性感染的基础
Macrophage activation during experimental murine brucellosis: a basis for chronic infection.
作者信息
Cheers C, Pagram F
出版信息
Infect Immun. 1979 Feb;23(2):197-205. doi: 10.1128/iai.23.2.197-205.1979.
Abstract
Evidence is presented that the chronicity of infection in CBA mice after injection of Brucella abortus 19 is related to a number of factors: (i) the relative resistance of B. abortus to macrophage killing, which allowed some bacteria to survive the peak of macrophage activity occurring at 14 days; (ii) the decline in macrophage activity thereafter (this decline was related in part to the presence of fewer bacteria to stimulate the bactericidal activity and also to specific, active suppressor mechanisms not identified in this study); and (iii) the insensitivity of the persistent Brucella organisms to activated macrophages. This was not due to a selection of genetically resistant bacteria, but possibly to their inaccessibility, either within "incompetent" macrophages or outside macrophages altogether.
摘要
有证据表明，注射流产布鲁氏菌19株后，CBA小鼠感染的慢性化与多种因素有关：（i）流产布鲁氏菌对巨噬细胞杀伤的相对抗性，这使得一些细菌能够在14天时巨噬细胞活性高峰时存活下来；（ii）此后巨噬细胞活性下降（这种下降部分与刺激杀菌活性的细菌数量减少有关，也与本研究中未确定的特定活性抑制机制有关）；（iii）持续存在的布鲁氏菌对活化巨噬细胞不敏感。这并非由于选择了具有遗传抗性的细菌，而是可能由于它们难以接近，要么在“无功能的”巨噬细胞内，要么完全在巨噬细胞外。
相似文献
1
Macrophage activation during experimental murine brucellosis: a basis for chronic infection.实验性小鼠布鲁氏菌病期间巨噬细胞的激活：慢性感染的基础
Infect Immun. 1979 Feb;23(2):197-205. doi: 10.1128/iai.23.2.197-205.1979.
2
Macrophage activation during experimental murine brucellosis. III. Do macrophages exert feedback control during brucellosis?实验性小鼠布鲁氏菌病期间的巨噬细胞激活。III. 巨噬细胞在布鲁氏菌病期间是否发挥反馈控制作用？
Cell Immunol. 1980 Jan;49(1):168-77. doi: 10.1016/0008-8749(80)90066-0.
3
Activated macrophages in congenitally athymic "nude mice" and in lethally irradiate mice.先天性无胸腺“裸鼠”及致死性照射小鼠体内的活化巨噬细胞。
J Immunol. 1975 Sep;115(3):844-7.
4
Inflammatory response of TLR4 deficient spleen macrophages (CRL 2471) to Brucella abortus S19 and an isogenic ΔmglA deletion mutant.Toll样受体4缺陷型脾巨噬细胞（CRL 2471）对流产布鲁氏菌S19及同基因ΔmglA缺失突变体的炎症反应
Int J Med Microbiol. 2016 May;306(3):141-51. doi: 10.1016/j.ijmm.2016.02.006. Epub 2016 Feb 20.
5
Comparison of Brucella abortus and Brucella melitensis infections of mice and their effect on acquired cellular resistance.小鼠感染流产布鲁氏菌和羊种布鲁氏菌的比较及其对获得性细胞抵抗力的影响。
Infect Immun. 1979 Nov;26(2):680-5. doi: 10.1128/iai.26.2.680-685.1979.
6
Macrophage activation during experimental murine brucellosis. II. Inhibition of in vitro lymphocyte proliferation by brucella-activated macrophages.实验性小鼠布鲁氏菌病期间的巨噬细胞激活。II. 布鲁氏菌激活的巨噬细胞对体外淋巴细胞增殖的抑制作用
Cell Immunol. 1980 Jan;49(1):154-67. doi: 10.1016/0008-8749(80)90065-9.
7
Effects of gamma radiation and azathioprine on Brucella abortus infection in BALB/c mice.γ辐射和硫唑嘌呤对BALB/c小鼠布鲁氏菌感染的影响。
Am J Vet Res. 1991 Jun;52(6):838-44.
8
The immunomodulatory effect of antimicrobial peptide HPA3P restricts Brucella abortus 544 infection in BALB/c mice.抗菌肽 HPA3P 的免疫调节作用限制了布鲁氏菌 abortus 544 在 BALB/c 小鼠中的感染。
Vet Microbiol. 2018 Nov;225:17-24. doi: 10.1016/j.vetmic.2018.09.005. Epub 2018 Sep 13.
9
Chronic Brucella Infection Induces Selective and Persistent Interferon Gamma-Dependent Alterations of Marginal Zone Macrophages in the Spleen.慢性布鲁氏菌感染诱导脾脏边缘区巨噬细胞发生选择性且持续的γ-干扰素依赖性改变。
Infect Immun. 2017 Oct 18;85(11). doi: 10.1128/IAI.00115-17. Print 2017 Nov.
10
Delayed type hypersensitivity-associated disruption of splenic periarteriolar lymphatic sheaths coincides with temporary loss of IFN-gamma production and impaired eradication of bacteria in Brucella abortus-infected mice.
Microbes Infect. 2003 Feb;5(2):95-106. doi: 10.1016/s1286-4579(02)00076-x.
引用本文的文献
1
What have we learned from brucellosis in the mouse model?从鼠模型中我们了解到了哪些关于布鲁氏菌病的知识？
Vet Res. 2012 Apr 13;43(1):29. doi: 10.1186/1297-9716-43-29.
2
Natural antibody contributes to host defense against an attenuated Brucella abortus virB mutant.天然抗体有助于宿主抵御减毒布鲁氏菌流产杆菌virB突变体。
Infect Immun. 2009 Jul;77(7):3004-13. doi: 10.1128/IAI.01114-08. Epub 2009 Apr 13.
3
Interferon-gamma is crucial for surviving a Brucella abortus infection in both resistant C57BL/6 and susceptible BALB/c mice.干扰素-γ对于抵抗布鲁氏菌感染的C57BL/6抗性小鼠和易感的BALB/c小鼠的存活至关重要。
Immunology. 2001 Aug;103(4):511-8. doi: 10.1046/j.1365-2567.2001.01258.x.
4
Deletion of purE attenuates Brucella melitensis infection in mice.purE基因的缺失减弱了小鼠体内的布鲁氏菌感染。
Infect Immun. 1996 Jun;64(6):2188-92. doi: 10.1128/iai.64.6.2188-2192.1996.
5
Oral immunization of mice and swine with an attenuated Salmonella choleraesuis [delta cya-12 delta(crp-cdt)19] mutant containing a recombinant plasmid.用含有重组质粒的减毒猪霍乱沙门氏菌[δcya-12 δ(crp-cdt)19]突变体对小鼠和猪进行口服免疫。
Infect Immun. 1993 Feb;61(2):610-8. doi: 10.1128/iai.61.2.610-618.1993.
6
Cytokine production in the murine response to brucella infection or immunization with antigenic extracts.小鼠对布鲁氏菌感染或用抗原提取物免疫反应中的细胞因子产生。
Immunology. 1993 Nov;80(3):458-64.
7
Vaccination with Brucella abortus rough mutant RB51 protects BALB/c mice against virulent strains of Brucella abortus, Brucella melitensis, and Brucella ovis.用粗糙型布鲁氏菌突变株RB51对BALB/c小鼠进行疫苗接种，可使其免受强毒株布鲁氏菌流产亚种、布鲁氏菌羊种和布鲁氏菌绵羊种的侵害。
Infect Immun. 1994 Nov;62(11):4990-6. doi: 10.1128/iai.62.11.4990-4996.1994.
8
Cell response to a salt-extractable and sonicated Brucella melitensis 16M antigen in human brucellosis.人布鲁氏菌病中细胞对盐可提取及超声处理的羊种布鲁氏菌16M抗原的反应
Clin Diagn Lab Immunol. 1995 May;2(3):377-80. doi: 10.1128/cdli.2.3.377-380.1995.
9
Immunomodulation by Blastomyces dermatitidis: functional activity of murine peritoneal macrophages.皮炎芽生菌的免疫调节作用：小鼠腹腔巨噬细胞的功能活性
Infect Immun. 1983 May;40(2):733-40. doi: 10.1128/iai.40.2.733-740.1983.
10
Characterization of macrophage functions in mice infected with Brucella abortus.感染牛布鲁氏菌的小鼠巨噬细胞功能的表征
Infect Immun. 1981 Jun;32(3):1079-83. doi: 10.1128/iai.32.3.1079-1083.1981.
本文引用的文献
1
Sensitization and recall of anti-Brucella immunity in Guinea pig macrophages by attenuated and virulent Brucella.减毒和强毒布鲁氏菌对豚鼠巨噬细胞抗布鲁氏菌免疫的致敏和回忆作用。
Infect Immun. 1971 Feb;3(2):200-8. doi: 10.1128/iai.3.2.200-208.1971.
2
THE PASSIVE TRANSFER OF ACQUIRED RESISTANCE TO LISTERIA MONOCYTOGENES.获得性抗单核细胞增生李斯特菌抗性的被动转移
J Exp Med. 1964 Jul 1;120(1):93-103. doi: 10.1084/jem.120.1.93.
3
THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE.获得性细胞抗性的免疫学基础。
J Exp Med. 1964 Jul 1;120(1):105-20. doi: 10.1084/jem.120.1.105.
4
THE BASIS FOR IMMUNITY TO MOUSE TYPHOID. I. THE CARRIER STATE.小鼠伤寒免疫的基础。一、带菌状态。
Aust J Exp Biol Med Sci. 1964 Apr;42:215-28. doi: 10.1038/icb.1964.23.
5
Relationship of allergy to gross lung disease and culturable bacilli in tuberculous mice.结核小鼠中变态反应与严重肺部疾病及可培养杆菌的关系。
Am Rev Tuberc. 1958 Aug;78(2):226-34. doi: 10.1164/artpd.1958.78.2.226.
6
The use of streptomycin-resistant and nonresistant strains for the determination of the immunizing effect of living Brucella abortus vaccines in white mice.使用抗链霉素和非抗链霉素菌株测定活布鲁氏菌流产疫苗对小白鼠的免疫效果。
J Infect Dis. 1954 May-Jun;94(3):213-24. doi: 10.1093/infdis/94.3.213.
7
The steady state in cellular immunity. II. Immunological complaisance in murine pertussis.细胞免疫中的稳态。II. 小鼠百日咳中的免疫顺应性
Aust J Exp Biol Med Sci. 1967 Aug;45(4):417-26. doi: 10.1038/icb.1967.40.
8
The steady state in cellular immunity. I. Chemotherapy and superinfection in murine tuberculosis.细胞免疫中的稳态。I. 小鼠结核病中的化疗与重复感染
Aust J Exp Biol Med Sci. 1967 Aug;45(4):407-16. doi: 10.1038/icb.1967.39.
9
10
The relative importance of blood monocytes and fixed macrophages to the expression of cell-mediated immunity to infection.血液单核细胞和固定巨噬细胞在细胞介导的抗感染免疫表达中的相对重要性。
J Exp Med. 1970 Sep 1;132(3):521-34. doi: 10.1084/jem.132.3.521.
Zotero 插件