Young E J, Gomez C I, Yawn D H, Musher D M
Infect Immun. 1979 Nov;26(2):680-5. doi: 10.1128/iai.26.2.680-685.1979.
By using mice infected with strains of Brucella abortus and Brucella melitensis we examined the histological responses to infection, the relationship of histology to persistence of organisms, and the relation of persistence of organisms to the acquisition of acquired cellular resistance (ACR). Infection with B. abortus resulted in well-formed granulomas in the livers, which persisted for more than 30 days. In contrast, infection with B. melitensis produced microabscesses in the livers which resolved before 30 days. The clearance of organisms from the tissues was also different. A total of 30 days after infection, large numbers of viable bacteria were recovered from the tissues of B. abortus-infected mice whereas bacteria were no longer recoverable from B. melitensis-infected animals. ACR to Listeria monocytogenes, another intracellular pathogen, persisted for more than 30 days in B. abortus-infected mice but waned rapidly in B. melitensis-infected animals. This disappearance of ACR due to B. melitensis paralleled the clearance of bacteria from the tissues.
通过使用感染了流产布鲁氏菌和羊种布鲁氏菌菌株的小鼠，我们研究了对感染的组织学反应、组织学与病原体持续存在的关系，以及病原体持续存在与获得性细胞抗性（ACR）获得的关系。感染流产布鲁氏菌会在肝脏中形成结构良好的肉芽肿，持续超过30天。相比之下，感染羊种布鲁氏菌会在肝脏中产生微脓肿，在30天前消退。病原体从组织中的清除情况也有所不同。感染后30天，从感染流产布鲁氏菌的小鼠组织中可回收大量活细菌，而从感染羊种布鲁氏菌的动物组织中则无法再回收细菌。对另一种细胞内病原体单核细胞增生李斯特菌的ACR在感染流产布鲁氏菌的小鼠中持续超过30天，但在感染羊种布鲁氏菌的动物中迅速减弱。由羊种布鲁氏菌导致的ACR消失与细菌从组织中的清除情况平行。
