Rohrwasser A, Morgan T, Dillon H F, Zhao L, Callaway C W, Hillas E, Zhang S, Cheng T, Inagami T, Ward K, Terreros D A, Lalouel J M
Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, USA.
Hypertension. 1999 Dec;34(6):1265-74. doi: 10.1161/01.hyp.34.6.1265.
The renin-angiotensin system is a major regulator of body sodium, predominantly through the actions of intrarenal angiotensin II of unclear origin. We show that polarized epithelium of the proximal tubule synthesizes and secretes angiotensinogen at its apical side and that the protein can be detected in urine as a function of dietary sodium. Furthermore, we demonstrate that renin is expressed and secreted in a restricted nephron segment, the connecting tubule, also in a sodium-dependent fashion. A paracrine renin-angiotensin system operating along the entire nephron may contribute to long-term arterial pressure regulation by integrating distant tubular sodium-reabsorbing functions.
肾素-血管紧张素系统是机体钠的主要调节因子，主要通过来源不明的肾内血管紧张素II起作用。我们发现近端小管的极化上皮细胞在其顶端侧合成并分泌血管紧张素原，并且该蛋白可作为饮食钠的函数在尿液中检测到。此外，我们证明肾素也以钠依赖的方式在肾单位的一个特定节段——连接小管中表达和分泌。沿整个肾单位运行的旁分泌肾素-血管紧张素系统可能通过整合远处肾小管的钠重吸收功能，对长期动脉血压调节起作用。
