Poliakov A V, Schieber M H
Departments of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642, USA.
J Neurophysiol. 1999 Dec;82(6):3488-505. doi: 10.1152/jn.1999.82.6.3488.
Primary motor cortex (M1) hand area neurons show patterns of discharge across a set of individuated finger and wrist movements so diverse as to preclude classifying the neurons into functional groups on the basis of simple inspection. We therefore applied methods of cluster analysis to search M1 neuronal populations for groups of neurons with similar patterns of discharge across the set of movements. Populations from each of three monkeys showed a large group of neurons the discharge of which increased for many or all of the movements and a second small group the discharge of which decreased for many or all movements. Two to three other small groups of neurons that discharged more specifically for one or two movements also were found in each monkey, but these groups were less consistent than the groups with broad movement fields. The limited functional grouping of M1 hand area neurons suggests that M1 neurons act as a network of highly diverse elements in controlling individuated finger movements.
初级运动皮层（M1）手部区域的神经元在一系列个体化的手指和腕部运动中表现出多样的放电模式，以至于无法通过简单观察将这些神经元归类为功能组。因此，我们应用聚类分析方法，在M1神经元群体中寻找在这一系列运动中具有相似放电模式的神经元组。来自三只猴子的神经元群体均显示出一大组神经元，其放电在许多或所有运动中增加，以及第二小组神经元，其放电在许多或所有运动中减少。在每只猴子中还发现了另外两到三组更特异性地针对一两种运动放电的小神经元组，但这些组不如具有广泛运动场的组一致。M1手部区域神经元有限的功能分组表明，M1神经元在控制个体化手指运动时作为一个高度多样化元素的网络发挥作用。
