Hu X, Chen H, Zhang X
Department of Chemistry, The Pennsylvania State University, University Park, PA 16802 (USA).
Angew Chem Int Ed Engl. 1999 Dec 3;38(23):3518-3521. doi: 10.1002/(sici)1521-3773(19991203)38:23<3518::aid-anie3518>3.0.co;2-p.
High enantioselectivity (up to 98 % ee) has been achieved for the conjugate addition of diethylzinc to acyclic enones utilizing Cu(I) complexes of the novel chiral P,N ligands 1. The high enantioselectivities are best achieved using Cu(OTf) small middle dotC(6)H(6) as the copper catalyst precursor in nonpolar solvents such as toluene or Cl(CH(2))(2)Cl. R=H, CH(3); Tf=F(3)CSO(2).
利用新型手性P，N配体1的Cu（I）配合物，实现了二乙基锌与开链烯酮的共轭加成反应的高对映选择性（高达98％ee）。使用[Cu（OTf）]₂·C₆H₆作为铜催化剂前体，在甲苯或Cl（CH₂）₂Cl等非极性溶剂中能最好地实现高对映选择性。R = H，CH₃；Tf = F₃CSO₂ 。
