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萨索林醇——神经毒性还是神经保护？

Salsolinol-neurotoxic or Neuroprotective?

机构信息

Department of Pathophysiology, Faculty of Medicine, Jagiellonian University Medical College, Czysta 18, 31-121, Krakow, Poland.

Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.

出版信息

Neurotox Res. 2020 Feb;37(2):286-297. doi: 10.1007/s12640-019-00118-7. Epub 2019 Nov 15.

DOI:10.1007/s12640-019-00118-7
PMID:31732870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6989573/
Abstract

Salsolinol (6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline), widely available in many edibles, is considered to alter the function of dopaminergic neurons in the central nervous system and thus, multiple hypotheses on its either physiological and/or pathophysiological role have emerged. The aim of our work was to revisit its potentially neurotoxic and/or neuroprotective role through a series of both in vitro and in vivo experiments. Salsolinol in the concentration range 10-250 μM did not show any significant release of lactate dehydrogenase from necrotic SH-SY5Y cells and was able in the concentration of 50 and 100 μM to rescue SH-SY5Y cells from death induced by HO. Its neuroprotective effect against neurotoxin 6-hydroxydopamine was also determined. Salsolinol was found to decrease significantly the reactive oxygen species level in SH-SY5Y cells treated by 500 μM HO and the caspase activity induced by 300 μM of HO or 100 μM of 6-hydroxydopamine. Serum levels of TNFα and CRP of salsolinol-treated rats were not significantly different from control animals. Both TNFα and CRP served as indirect markers of neurotoxicity and/or neuroprotection. Although the neurotoxic properties of salsolinol have numerously been emphasized, its neuroprotective properties should not be neglected and need greater consideration.

摘要

萨索林醇（6,7-二羟基-1-甲基-1,2,3,4-四氢异喹啉）广泛存在于许多食品中，被认为会改变中枢神经系统中多巴胺能神经元的功能，因此，关于其生理和/或病理生理作用的多种假说已经出现。我们的工作旨在通过一系列体外和体内实验重新研究其潜在的神经毒性和/或神经保护作用。萨索林醇在 10-250 μM 的浓度范围内不会引起坏死的 SH-SY5Y 细胞中乳酸脱氢酶的显著释放，并且能够在 50 和 100 μM 的浓度下挽救 SH-SY5Y 细胞免受 HO 诱导的死亡。它对神经毒素 6-羟多巴胺的神经保护作用也得到了确定。发现萨索林醇可显著降低 500 μM HO 处理的 SH-SY5Y 细胞中的活性氧水平，并降低 300 μM HO 或 100 μM 6-羟多巴胺诱导的半胱天冬酶活性。萨索林醇处理大鼠的血清 TNFα 和 CRP 水平与对照动物无显著差异。TNFα 和 CRP 均作为神经毒性和/或神经保护的间接标志物。尽管萨索林醇的神经毒性特性已被多次强调，但不应忽视其神经保护特性，需要更多的考虑。

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