Musshoff F, Daldrup T, Bonte W, Leitner A, Lesch O M
Institute of Legal Medicine, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.
Pharmacol Biochem Behav. 1997 Oct;58(2):545-50. doi: 10.1016/s0091-3057(97)00251-7.
The tetrahydroisoquinoline alkaloids salsolinol and norsalsolinol were found in human urine samples in concentrations ranging from 0.1 to 29.5 ng/ml. Great interindividual variation was found in urine levels of these alkaloids in a collection of chronic alcoholics and in a group of nonalcoholics. Thus, levels of the individual alkaloids are insufficient markers for distinguishing between alcoholics and nonalcoholics. However, by using the concentration ratio of norsalsolinol and salsolinol, the so-called dopamine-aldehyde adduct ratio (DAAR), significant differences between alcoholics (median 1.3) and nonalcoholics (median 0.6) were detected. This concentration ratio could serve as a marker for the processor state of the dopaminergic system.
在人类尿液样本中发现了四氢异喹啉生物碱萨索林醇和去甲萨索林醇，其浓度范围为0.1至29.5纳克/毫升。在一组慢性酗酒者和一组非酗酒者中，发现这些生物碱的尿液水平存在很大的个体差异。因此，单个生物碱的水平不足以作为区分酗酒者和非酗酒者的标志物。然而，通过使用去甲萨索林醇和萨索林醇的浓度比，即所谓的多巴胺-醛加合物比（DAAR），检测到酗酒者（中位数1.3）和非酗酒者（中位数0.6）之间存在显著差异。这个浓度比可以作为多巴胺能系统加工状态的标志物。
