Gang N, Langevitz P, Livneh A
Department of Medicine F, Sheba Medical Center, Tel-Hashomer, Israel.
Am J Gastroenterol. 1999 Dec;94(12):3626-8. doi: 10.1111/j.1572-0241.1999.01621.x.
We report a 75-yr-old patient, who presented three times with acute pancreatitis, accompanied by high temperature, shock, and multiorgan involvement and associated each time with exposure to the cholesterol lowering agent bezafibrate. Extensive workup excluded other possible causes for recurrent pancreatitis in this patient, further supporting bezafibrate as the cause of the patient's acute illness. Based on the short time elapsing between rechallenge and development of manifestations and the specific features of the attacks, we proposed hypersensitivity to bezafibrate as the underlying mechanism. The present report includes, for the first time, bezafibrate among definite causes of acute pancreatitis.
我们报告了一位75岁的患者，该患者曾三次出现急性胰腺炎，伴有高热、休克及多器官受累，且每次发病均与使用降胆固醇药物苯扎贝特有关。全面检查排除了该患者复发性胰腺炎的其他可能病因，进一步支持苯扎贝特为该患者急性疾病的病因。基于再次用药与症状出现之间的时间间隔较短以及发作的特定特征，我们提出对苯扎贝特过敏是潜在机制。本报告首次将苯扎贝特列入急性胰腺炎的确切病因之中。
