Nigwekar Sagar U, Casey Kevin J
Department of Internal Medicine, Rochester General Hospital, Rochester, NY 14621, USA.
JOP. 2004 Nov 10;5(6):516-9.
Pancreatitis is a very rare adverse effect of metronidazole with only six cases of metronidazole-induced pancreatitis reported in the English literature so far.
We report a case of recurrent acute pancreatitis in a 46-year-old female associated with oral metronidazole therapy and review the literature with regards to metronidazole-induced pancreatitis. We are also highlighting the fact that the time lag between metronidazole exposure and development of pancreatitis is very variable.
High degree of suspicion is warranted on the part of physicians to diagnose metronidazole induced pancreatitis in patients presenting with gastrointestinal symptoms after metronidazole exposure. If metronidazole is suspected as the causative agent then it should be discontinued and rechallenge should be avoided.
胰腺炎是甲硝唑非常罕见的不良反应，迄今为止英文文献中仅报道了6例甲硝唑诱发的胰腺炎病例。
我们报告了1例46岁女性复发性急性胰腺炎病例，该病例与口服甲硝唑治疗有关，并回顾了关于甲硝唑诱发胰腺炎的文献。我们还强调了甲硝唑暴露与胰腺炎发生之间的时间间隔变化很大这一事实。
对于在接触甲硝唑后出现胃肠道症状的患者，医生有必要高度怀疑甲硝唑诱发的胰腺炎。如果怀疑甲硝唑是病因，则应停药并避免再次使用。
