Juniper E F, Thompson A K, Ferrie P J, Roberts J N
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Clin Exp Allergy. 2000 Jan;30(1):132-40. doi: 10.1046/j.1365-2222.2000.00668.x.
The 28-item Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) has strong measurement properties but for large clinical trials, surveys and practice monitoring, where high efficiency is important, a shorter questionnaire is needed.
To develop and validate an abbreviated version of the RQLQ.
Using five RQLQ databases, items with high item-item correlations were combined and then the highest scoring items were selected for the MiniRQLQ (14 questions). There are five domains: activity limitations (standardized), practical problems and nose symptoms, eye symptoms and other symptoms. The MiniRQLQ, which is self-administered, was tested in a 5-week observational study in 100 adults with symptomatic rhinoconjunctivitis. Patients completed the MiniRQLQ, the RQLQ, and other measures of health status at baseline, 1 and 5 weeks.
In patients whose rhinoconjunctivitis was stable between clinic visits, reliability (reproducibility and ability to discriminate between patients of different impairment) was very acceptable for the MiniRQLQ (ICC = 0.93) but not quite as good as for the RQLQ (ICC = 0.97). Responsiveness to change in clinical status was better with the MiniRQLQ than the RQLQ (P = 0. 044). Construct validity (correlation with other indices of health status) was strong for both the MiniRQLQ and the RQLQ. Concordance between the two instruments was high (ICC = 0.87).
The MiniRQLQ has strong measurement properties and measures the same construct as the original RQLQ. The choice of questionnaire should depend on the task at hand.
28项变应性鼻炎生活质量问卷（RQLQ）具有很强的测量属性，但对于大型临床试验、调查和实践监测而言，在高效性很重要的情况下，需要一份更简短的问卷。
开发并验证RQLQ的简化版本。
利用五个RQLQ数据库，将具有高项目间相关性的项目合并，然后为简化变应性鼻炎生活质量问卷（MiniRQLQ，14个问题）选择得分最高的项目。有五个领域：活动受限（标准化）、实际问题和鼻部症状、眼部症状及其他症状。自我填写的MiniRQLQ在一项为期5周的观察性研究中对100名有症状的变应性鼻炎成年患者进行了测试。患者在基线、第1周和第5周完成了MiniRQLQ、RQLQ及其他健康状况测量。
在门诊就诊期间变应性鼻炎病情稳定的患者中，MiniRQLQ的可靠性（可重复性以及区分不同损伤程度患者的能力）非常令人满意（组内相关系数[ICC]=0.93），但不如RQLQ（ICC=0.97）。MiniRQLQ对临床状态变化的反应性优于RQLQ（P=0.044）。MiniRQLQ和RQLQ的结构效度（与其他健康状况指标的相关性）都很强。两种工具之间的一致性很高（ICC=0.87）。
MiniRQLQ具有很强的测量属性，且与原始RQLQ测量的是相同的结构。问卷的选择应取决于手头的任务。
