Soler R, de la Hoz B, Badia X, Mercadal J, Lozano R, Benavides A, Roset M
Hospital Son Dureta, Mallorca.
Rev Clin Esp. 2004 Mar;204(3):131-8. doi: 10.1157/13058825.
Validate the questionnaire Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) in conditions of regular clinical practice.
Two hundred and eighty four adult patients with a diagnosis of rhinoconjunctivitis (RC) cared in 37 centers of specialized health care in allergy or otorhinolaryngology services in Spain were analyzed. Patients with RC were included in two groups: clinically non-stable patients who received treatment with an oral second generation antihistaminic (group A), and clinically stable patients (group B). Sociodemographic and clinical variables were collected and the questionnaires RQLQ and EQ-5D were administered in the initial visit and in the second visit 15 days after. Feasibility, validity, reliability and sensitivity related to the change of the RQLQ were analyzed.
The mean period (standard deviation) of administration was 9.67 (6.25) minutes and 85.6% of patients needed assistance in order to fill the RQLQ, especially the selection of the characteristics (62.5%). The dimensions of the RQLQ showed a greater association with the dimensions of the EQ-5D that assessed similar aspects and the symptoms in which a greater relation was expected. The alpha Cronbach coefficient of the scorings of the RQLQ fluctuated between 0.85 and 0.96 and the intraclass correlation coefficient fluctuated between 0.68 and 0.89. The sensitivity to the change of the dimensions of the RQLQ, evaluated through the magnitude of the effect between the two visits, ranged between 0.76 and 1.46.
The Spanish version of the RQLQ proved to be a valid instrument for assessing the Health-Related Quality of Life (HRQL) in adult patients with seasonal or perennial RC.
在常规临床实践条件下验证变应性鼻炎生活质量问卷（RQLQ）。
对西班牙37个过敏或耳鼻咽喉科专科医疗中心诊治的284例诊断为变应性鼻炎（RC）的成年患者进行分析。患有RC的患者分为两组：接受口服第二代抗组胺药治疗的临床不稳定患者（A组）和临床稳定患者（B组）。收集社会人口统计学和临床变量，并在初诊时和15天后的第二次就诊时发放RQLQ问卷和EQ-5D问卷。分析RQLQ与变化相关的可行性、有效性、可靠性和敏感性。
问卷平均发放时间（标准差）为9.67（6.25）分钟，85.6%的患者需要协助填写RQLQ，尤其是在特征选择方面（62.5%）。RQLQ的维度与评估相似方面的EQ-5D维度以及预期有更大关联的症状显示出更大的相关性。RQLQ评分的Cronbach α系数在0.85至0.96之间波动，组内相关系数在0.68至0.89之间波动。通过两次就诊之间的效应大小评估的RQLQ维度对变化的敏感性在0.76至1.46之间。
RQLQ西班牙语版被证明是评估季节性或常年性RC成年患者健康相关生活质量（HRQL）的有效工具。
