Bate M
Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK.
Curr Opin Neurobiol. 1999 Dec;9(6):670-5. doi: 10.1016/s0959-4388(99)00031-8.
The development of motor behaviour depends on the differentiation of underlying circuitry. Recent work with the zebrafish brings the simple swimming behaviour of lower vertebrates and their embryos into focus as a suitable model to study the development of motor circuitry and its genetic control. Changes in connectivity and excitability contribute to the development of swimming in this simple system. In the chick embryo, limb motor circuitry is spontaneously active before motor axons reach their muscle targets, and it has properties in common with the spontaneously active networks in the retina. The early rhythmic activity responsible for embryonic movement is probably a generalised property of developing spinal networks that precedes, and may be required for, the completion of functional locomotor circuitry.
运动行为的发展依赖于潜在神经回路的分化。最近对斑马鱼的研究使低等脊椎动物及其胚胎的简单游泳行为成为研究运动神经回路发育及其基因控制的合适模型。在这个简单系统中，连接性和兴奋性的变化有助于游泳行为的发展。在鸡胚中，肢体运动神经回路在运动轴突到达其肌肉靶点之前就自发活动，并且它具有与视网膜中自发活动网络相同的特性。负责胚胎运动的早期节律性活动可能是发育中的脊髓网络的一种普遍特性，它先于功能性运动神经回路的形成，并且可能是其形成所必需的。
