主要组织相容性复合体超家族结构与免疫系统。
MHC superfamily structure and the immune system.
作者信息
Maenaka K, Jones E Y
机构信息
Structural Biology, Wellcome Trust Centre for Human Genetics, Headington, OX3 7BN, UK.
出版信息
Curr Opin Struct Biol. 1999 Dec;9(6):745-53. doi: 10.1016/s0959-440x(99)00039-1.
Abstract
During the past year, a plethora of structural information has provided detailed insights into the interactions between classical MHC class I molecules and their cognate receptors on T cells. Likewise, there have been major advances in our knowledge of the structures and functions of five nonclassical MHC-like molecules: HLA-DM (murine H2-M), HLA-E, HFE, ZAG and MIC-A.
摘要
在过去的一年里，大量的结构信息为深入了解经典MHC I类分子与其在T细胞上的同源受体之间的相互作用提供了详细的见解。同样，我们在五个非经典MHC类分子的结构和功能方面的知识也取得了重大进展，这五个分子分别是：HLA-DM（小鼠H2-M）、HLA-E、HFE、ZAG和MIC-A。
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