Cooper J D, Duffin J, Glynn M F, Nelems J M, Teasdale S, Scott A A, Martin B
J Thorac Cardiovasc Surg. 1976 Feb;71(2):304-8.
A 24-year-old woman with chronic granulocytic leukemia and alveolar proteinosis required extracorporeal membrane oxygenator support for respiratory failure refractory to conventional therapy. During perfusion, each lung was lavaged with 10 L. of normal saline. The lavage led to marked clearing of the lungs and improvement in pulmonary function. Extracorporeal support was terminated successfully after 54 hours. The patient died 2 weeks later with bone marrow insufficiency and overwhelming sepsis. Pulmonary lavage is technically feasible during venovenous oxygenator bypass, and may be of value, since such lavage debrides alveoli as well as the bronchial tree. Because pulmonary lavage provides a possible means of improving pulmonary function, it seems worthy of consideration as an adjunct to membrane oxygenator support.
一名患有慢性粒细胞白血病和肺泡蛋白沉积症的24岁女性因常规治疗难以控制的呼吸衰竭需要体外膜肺氧合支持。在灌注过程中，每侧肺用10升生理盐水进行灌洗。灌洗使肺部明显清晰，肺功能得到改善。54小时后成功终止体外支持。患者在2周后死于骨髓功能不全和严重脓毒症。在静脉-静脉氧合器旁路期间进行肺灌洗在技术上是可行的，并且可能有价值，因为这种灌洗可清除肺泡以及支气管树。由于肺灌洗提供了一种改善肺功能的可能方法，作为膜肺氧合支持的辅助手段似乎值得考虑。
