Collins P Y, Varma V K, Wig N N, Mojtabai R, Day R, Susser E
Department of Pyschiatry, College of Physicians and Surgeons of Columbia University, New York, USA.
Br J Psychiatry. 1999 Jun;174:520-4. doi: 10.1192/bjp.174.6.520.
This case-control study used data from Chandigarh, North India to investigate the association between antecedent fever and acute brief psychosis.
To assess whether antecedent fever may be a biological correlate of acute brief psychosis, and contribute to the nosology of acute brief psychosis.
The study was based in an incidence cohort from two catchment areas, an urban and a rural site, that were part of the World Health Organization Determinants of Outcome study. The cases (n = 17) met criteria for acute brief psychosis; controls (n = 40) were patients with other acute and subacute psychoses. The Life Events Schedule was used to determine the presence of antecedent fever.
The crude odds ratio for fever as a risk factor for acute brief psychosis was 6.2 (P = 0.004). The odds ratio in a logistic regression analysis--adjusted for site, gender and CATEGO classification--was 11.2 (P = 0.003).
Antecedent fever may be a biological correlate of acute brief psychosis. This finding supports the validity of this entity, and has implications for its aetiology and diagnosis.
这项病例对照研究使用了印度北部昌迪加尔的数据，以调查先前发热与急性短暂性精神病之间的关联。
评估先前发热是否可能是急性短暂性精神病的生物学相关因素，并对急性短暂性精神病的疾病分类学有所贡献。
该研究基于来自两个集水区（一个城市地区和一个农村地区）的发病率队列，这两个地区是世界卫生组织结局决定因素研究的一部分。病例组（n = 17）符合急性短暂性精神病的标准；对照组（n = 40）为患有其他急性和亚急性精神病的患者。使用生活事件量表来确定先前发热的情况。
发热作为急性短暂性精神病危险因素的粗比值比为6.2（P = 0.004）。在对地点、性别和CATEGO分类进行调整的逻辑回归分析中，比值比为11.2（P = 0.003）。
先前发热可能是急性短暂性精神病的生物学相关因素。这一发现支持了该实体的有效性，并对其病因学和诊断具有启示意义。
