Holmin T
Scand J Clin Lab Invest. 1976 Sep;36(5):423-9. doi: 10.3109/00365517609054459.
The influence of hepatectomy on cerebral energy metabolism was studied in rats in which an end-to-side portacaval anastomosis had been performed one week earlier. The hepatectomy gave rise to an exaggeration of the increase in tissue ammonia content resulting from the shunt. Three hours after the hepatectomy there was a fall in tissue glutamate content but no change in alpha-ketoglutarate. The energy state of the tissue, as evaluated from the concentrations of ATP, ADP, and AMP, was unchanged. There was a significant increase in cerebrospinal fluid pH but no change in intracellular pH.
在一周前已进行端侧门腔静脉吻合术的大鼠中，研究了肝切除术对脑能量代谢的影响。肝切除术导致分流引起的组织氨含量增加更为明显。肝切除术后三小时，组织谷氨酸含量下降，但α-酮戊二酸无变化。根据ATP、ADP和AMP的浓度评估的组织能量状态未改变。脑脊液pH值显著升高，但细胞内pH值无变化。
