Holmin T, Agardh C D, Alinder G, Herlin P, Hultberg B
Eur J Clin Invest. 1983 Jun;13(3):215-20. doi: 10.1111/j.1365-2362.1983.tb00090.x.
The influence of total hepatectomy on cerebral energy state, ammonia-related amino acids of the brain tissue and plasma amino acids was studied in anaesthetized rats after total hepatectomy. The hepatectomy was performed with the aid of a microsurgical three-stage procedure. In the first stage, division of the inferior vena cava was performed. In the second stage 4 weeks later a porta-caval anastomosis was constructed, followed after 1 week by a total hepatectomy. The brain energy state, defined as the concentrations of phosphocreatine, ATP, ADP and AMP, was unchanged 4 h after the hepatectomy. Plasma amino acids did not differ significantly between hepatectomized and shunted control rats. On the other hand, clear-cut increases in the concentrations of glutamine, and decreases in the concentrations of glutamate and aspartate, were observed in the fronto-parietal part of the cerebral cortex and the brain stem. These changes might explain the minor manifestations of cerebral dysfunction in the early phase of the hepatectomized state.
在麻醉大鼠全肝切除术后，研究了全肝切除术对脑组织能量状态、脑组织与血浆中氨相关氨基酸的影响。肝切除术借助显微外科三阶段手术进行。第一阶段，进行下腔静脉离断。4周后第二阶段构建门腔静脉吻合术，1周后进行全肝切除术。肝切除术后4小时，定义为磷酸肌酸、三磷酸腺苷（ATP）、二磷酸腺苷（ADP）和一磷酸腺苷（AMP）浓度的脑能量状态未发生变化。肝切除大鼠与分流对照大鼠的血浆氨基酸无显著差异。另一方面，在大脑皮层额顶叶部分和脑干中观察到谷氨酰胺浓度明显升高，谷氨酸和天冬氨酸浓度降低。这些变化可能解释了肝切除状态早期脑功能障碍的轻微表现。
