Arbustini E, Porcu E, Bellini O, Grasso M, Pilotto A, Dal Bello B, Morbini P, Diegoli M, Gavazzi A, Specchia G, Tavazzi L
Department of Pathology, IRCCS-Policlinico San Matteo, Pavia, Italy.
Heart. 2000 Jan;83(1):86-90. doi: 10.1136/heart.83.1.86.
Enteroviral RNA detection in myocarditis and dilated cardiomyopathy is rare. Enteroviral particles and RNA have recently been identified in patient's skeletal muscle, suggesting that skeletal more than heart muscle hosts the virus in chronic infection. Enteroviral RNA and virus-like particles were found in the myocardium and in the skeletal muscle of two patients with fatal myocarditis: a 39 year old man who died five days after the onset of febrile flu; and a 49 year old woman, assisted for 50 days with a left ventricular assist device, who then died from cerebral haemorrhage. Automated sequencing, alignment, and sequence comparison confirmed the enteroviral origin of polymerase chain reaction products and excluded contamination. These findings agree with prior observations of enteroviral localisation in the skeletal muscle of patients with dilated cardiomyopathy, and further support the hypothesis that skeletal rather than heart muscle may host the virus and serve as a reservoir in cardiomyopathies related to chronic infection.
enterovirus; myocarditis; viral particles; skeletal muscle
在心肌炎和扩张型心肌病中检测到肠道病毒RNA的情况很少见。最近在患者的骨骼肌中发现了肠道病毒颗粒和RNA，这表明在慢性感染中，病毒在骨骼肌中的寄生情况多于心肌。在两名致命心肌炎患者的心肌和骨骼肌中发现了肠道病毒RNA和病毒样颗粒：一名39岁男性，在发热性流感发作五天后死亡；一名49岁女性，使用左心室辅助装置50天，随后死于脑出血。自动测序、比对和序列比较证实了聚合酶链反应产物的肠道病毒来源，并排除了污染。这些发现与之前关于扩张型心肌病患者骨骼肌中肠道病毒定位的观察结果一致，并进一步支持了这样的假设，即在与慢性感染相关的心肌病中，病毒可能寄生在骨骼肌而非心肌中，并作为一个储存库。
肠道病毒；心肌炎；病毒颗粒；骨骼肌
