Michelmore K F, Balen A H, Dunger D B, Vessey M P
Division of Public Health and Primary Care, Institute of Health Sciences, Oxford, UK.
Clin Endocrinol (Oxf). 1999 Dec;51(6):779-86. doi: 10.1046/j.1365-2265.1999.00886.x.
To determine the prevalence of polycystic ovaries as identified by ultrasound in a group of young, postmenarcheal women in the normal population, and to investigate how polycystic ovaries are related to the spectrum of clinical and biochemical symptoms associated with the polycystic ovary syndrome (PCOS).
Cross-sectional observational study.
Volunteers were recruited from two universities and two general practice surgeries in Oxford. 230 women aged 18-25 years participated. Information collected and measurements performed included: a menstrual history, anthropometric measurements, clinical observation of acne and hirsutism, transabdominal pelvic ultrasound, and biochemical analysis of a fasting blood sample.
Prevalence of polycystic ovaries and their association with symptoms of the polycystic ovary syndrome.
Polycystic ovarian morphology was identified in 74 (33%, 95% CI = 27-39%) of the 224 women who attended for an ultrasound scan. In the non-users of hormonal contraception, irregular menstrual cycles were 20% more common in women with polycystic ovaries than in women with normal ovaries (P = 0.07). There were no significant differences in acne, hirsutism, body mass index or body fat percentage between women with polycystic and normal ovaries. Analysis of biochemical data showed that women with polycystic ovaries had higher total serum testosterone concentrations (P = 0.03). The prevalence of PCOS in this age group was as low as 8% or as high as 26% depending on which criteria were applied to define the syndrome. Sub-group analyses of women according to ovarian morphology and features of PCOS revealed greater mean BMI in women with PCOS, and also indicated lower fasting insulin concentrations and greater insulin sensitivity in polycystic ovary and PCOS groups when compared to women with normal ovaries.
Polycystic ovaries are very common in this age group but are not necessarily associated with other symptomatology. The prevalence of polycystic ovary syndrome varies widely according to the definition applied. Sub-group analysis of women with polycystic ovaries according to the presence or absence of features of polycystic ovary syndrome does not reveal an increasing trend for progression of endocrine abnormalities usually associated with polycystic ovary syndrome.
确定超声检查发现的多囊卵巢在一组正常人群中初潮后年轻女性中的患病率，并研究多囊卵巢与多囊卵巢综合征（PCOS）相关的一系列临床和生化症状之间的关系。
横断面观察性研究。
志愿者来自牛津的两所大学和两个全科医疗诊所。230名年龄在18 - 25岁的女性参与研究。收集的信息和进行的测量包括：月经史、人体测量、痤疮和多毛症的临床观察、经腹盆腔超声检查以及空腹血样的生化分析。
多囊卵巢的患病率及其与多囊卵巢综合征症状的关联。
在接受超声扫描的224名女性中，74名（33%，95%置信区间 = 27 - 39%）被发现有多囊卵巢形态。在未使用激素避孕的女性中，多囊卵巢女性的月经周期不规律比正常卵巢女性常见20%（P = 0.07）。多囊卵巢女性与正常卵巢女性在痤疮、多毛症、体重指数或体脂百分比方面无显著差异。生化数据分析显示，多囊卵巢女性的血清总睾酮浓度较高（P = 0.03）。根据用于定义该综合征的标准不同，这个年龄组中PCOS的患病率低至8%或高达26%。根据卵巢形态和PCOS特征对女性进行亚组分析发现，PCOS女性的平均体重指数更高，并且与正常卵巢女性相比，多囊卵巢组和PCOS组的空腹胰岛素浓度更低，胰岛素敏感性更高。
多囊卵巢在这个年龄组中非常常见，但不一定与其他症状相关。根据所应用的定义，多囊卵巢综合征的患病率差异很大。根据是否存在多囊卵巢综合征特征对多囊卵巢女性进行亚组分析，未发现通常与多囊卵巢综合征相关的内分泌异常进展的增加趋势。
