Westermann G W, Böhm M, Bonsmann G, Rahn K H, Kisters K
Department of Internal Medicine D, Westfälische Wilhelms-University, Münster, Germany.
J Intern Med. 1999 Dec;246(6):591-2. doi: 10.1046/j.1365-2796.1999.00606.x.
We report the clinical case of a 12-years' intoxication by doxycycline. A patient with a depersonalization and derealization syndrome took 1 g doxycycline per day. In addition to hepatocellular necrosis with cholestasis, nephrotoxicity, leukopenia, anaemia and skin hyperpigmentation he suffered from hitherto unreported adverse cardiac events as intermittent supraventricular tachycardia and sporadic Wenckebach heart block. Despite a long period of self-medication these side-effects were reversible.
我们报告了一例12年多来服用强力霉素中毒的临床病例。一名患有人格解体和现实解体综合征的患者每天服用1克强力霉素。除了肝细胞坏死伴胆汁淤积、肾毒性、白细胞减少、贫血和皮肤色素沉着外，他还出现了此前未报告的不良心脏事件，如间歇性室上性心动过速和散发性文氏心脏传导阻滞。尽管长期自行用药，但这些副作用是可逆的。
