Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, 4770 Buford Hwy., Atlanta, GA 30341, USA.
Am J Trop Med Hyg. 2011 Apr;84(4):517-31. doi: 10.4269/ajtmh.2011.10-0285.
Doxycycline, a synthetically derived tetracycline, is a partially efficacious causal prophylactic (liver stage of Plasmodium) drug and a slow acting blood schizontocidal agent highly effective for the prevention of malaria. When used in conjunction with a fast acting schizontocidal agent, it is also highly effective for malaria treatment. Doxycycline is especially useful as a prophylaxis in areas with chloroquine and multidrug-resistant Plasmodium falciparum malaria. Although not recommended for pregnant women and children < 8 years of age, severe adverse events are rarely reported for doxycycline. This report examines the evidence behind current recommendations for the use of doxycycline for malaria and summarizes the available literature on its safety and tolerability.
强力霉素，一种合成的四环素，是一种部分有效的因果预防药物（疟原虫的肝脏阶段），也是一种缓慢作用的血裂殖体杀灭剂，对预防疟疾非常有效。当与快速作用的裂殖体杀灭剂一起使用时，它对疟疾的治疗也非常有效。强力霉素在有氯喹和耐多药恶性疟原虫的地区特别有用。虽然不建议孕妇和 8 岁以下儿童使用，但强力霉素严重不良反应的报告很少。本报告审查了目前推荐使用强力霉素治疗疟疾的证据，并总结了有关其安全性和耐受性的现有文献。
