Nierenberg A A, Burt T, Matthews J, Weiss A P
Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Biol Psychiatry. 1999 Dec 15;46(12):1707-8. doi: 10.1016/s0006-3223(99)00233-4.
St. John's wort, the popular herbal remedy touted as an antidepressant, is generally thought to be benign, with few reported side effects. Given its possible efficacy as an antidepressant, evaluation of its propensity to cause affective switching should be evaluated.
This report presents two cases of mania temporally associated with the use of St. John's wort (hypericum).
As with other antidepressant agents, St. John's wort may precipitate hypomania, mania, or an increased cycling of mood states, particularly in patients with occult bipolar disorder.
Because the majority of people who take this popular over-the-counter preparation do so without formal psychiatric evaluations, risk of hypericum-induced mania may be significant. Physicians should screen patients for a history of hypomania or mania before recommending use of St. John's wort for depression.
圣约翰草，一种广受欢迎的被吹捧为抗抑郁药的草药疗法，通常被认为是无害的，报告的副作用很少。鉴于其作为抗抑郁药的潜在疗效，应评估其导致情感转换的倾向。
本报告介绍了两例与使用圣约翰草（金丝桃属植物）在时间上相关的躁狂症病例。
与其他抗抑郁药一样，圣约翰草可能会引发轻躁狂、躁狂或情绪状态循环增加，尤其是在患有隐匿性双相情感障碍的患者中。
由于大多数服用这种广受欢迎的非处方制剂的人没有经过正式的精神科评估，金丝桃属植物诱发躁狂的风险可能很大。医生在推荐使用圣约翰草治疗抑郁症之前，应筛查患者是否有轻躁狂或躁狂病史。
