Frederickson R C, Norris F H
Science. 1976 Oct 22;194(4263):440-2. doi: 10.1126/science.10625.
Enkephalin, applied microiontophoretically, depressed spontaneous and glutamate-induced firing of single neurons in frontal cortex, caudate nucleus, and periaqueductal gray matter, where enkephalin and high concentrations of opiate receptors are found. Many of the depressions were blocked by the specific narcotic antagonist naloxone. The data are compatible with a neurotransmitter or neuromodulator role for this new brain pentapeptide.
脑啡肽通过微量离子电泳法应用时，可抑制额叶皮质、尾状核和导水管周围灰质中单个神经元的自发放电以及谷氨酸诱导的放电，而在这些部位可发现脑啡肽和高浓度的阿片受体。许多这种抑制作用可被特异性麻醉拮抗剂纳洛酮阻断。这些数据与这种新的脑内五肽作为神经递质或神经调质的作用相一致。
